caa a22 4500 605544050 CHVBK 20210128100929.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00109-015-1357-0 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1357-0 Winkler Frank Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany aut The brain metastatic niche [Elektronische Daten] [Frank Winkler] Metastasizing cancer cells that arrest in brain microvessels have to face an organ microenvironment that is alien, and exclusive. In order to survive and thrive in this foreign soil, the malignant cells need to successfully master a sequence of steps that includes close interactions with pre-existing brain microvessels, and other nonmalignant cell types. Unfortunately, a relevant number of circulating cancer cells is capable of doing so: brain metastasis is a frequent and devastating complication of solid tumors, becoming ever more important in times where the systemic tumor disease is better controlled and life of cancer patients is prolonged. Thus, it is very important to understand which environmental cues are necessary for effective brain colonization. This review gives an overview of the niches we know, including those who govern cancer cell dormancy, survival, and proliferation in the brain. Colonization of pre-existing niches related to stemness and resistance is a hallmark of successful brain metastasis. A deeper understanding of those host factors can help to identify the most vulnerable steps of the metastatic cascade, which might be most amenable to therapeutic interventions. Springer-Verlag Berlin Heidelberg, 2015 Brain nationallicence Metastasis nationallicence Metastases nationallicence Blood-brain barrier nationallicence Perivascular nationallicence Niche nationallicence Journal of Molecular Medicine Springer Berlin Heidelberg 93/11(2015-11-01), 1213-1220 0946-2716 93:11<1213 2015 93 109 https://doi.org/10.1007/s00109-015-1357-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1357-0 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Winkler Frank Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/11(2015-11-01), 1213-1220 0946-2716 93:11<1213 2015 93 109