caa a22 4500 605544069 CHVBK 20210128100929.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00109-015-1342-7 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1342-7 Krüger Achim Institut für Molekulare Immunologie und Experimentelle Onkologie, Klinikum rechts der Isar der Technischen Universität München|, Ismaninger Str. 22, D-81675, München, Germany aut Premetastatic niche formation in the liver: emerging mechanisms and mouse models [Elektronische Daten] [Achim Krüger] The liver is recognized as the target organ of metastases of almost all prominent malignancies. Its unique biology renders this organ particularly susceptible to circulating disseminated tumour cells (DTCs), and it can be assumed that very early metastasis occurs in the liver. The premetastatic niche concept may explain very early metastasis, as it defines priming of a future target organ of metastasis by factors that may already be secreted from premalignant lesions. This review shows that comprehensive knowledge on mechanisms of premetastatic niche formation in the liver is based on pre-clinical models only and still rather rare, mostly due to the scarcity of mouse liver metastasis models displaying a tumour cell-free period in the liver or lack of liver-tropic syngeneic tumour cells to probe for the niche. Attentive re-assessment of previous studies and reviews was undertaken revealing only two clearly identified tumour-derived secreted factors (TDSFs), both inducing infiltration of the liver by bone marrow-derived cells and increased liver metastasis, namely tissue inhibitor of metalloproteinases-1 (TIMP-1) and macrophage-inducing factor (MIF). Future directions of this research area will comprise elucidation of the impact of TDSFs on regulation and activity of myeloid-derived suppressor cells and/or the specific architecture and homeostasis of the liver, as well as development of prognostic TDSF detection in patients at risk of liver metastasis. Springer-Verlag Berlin Heidelberg, 2015 Liver metastasis nationallicence Premetastatic niche nationallicence Sinusoids nationallicence MDSCs nationallicence TIMP-1 nationallicence MIF nationallicence Journal of Molecular Medicine Springer Berlin Heidelberg 93/11(2015-11-01), 1193-1201 0946-2716 93:11<1193 2015 93 109 https://doi.org/10.1007/s00109-015-1342-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1342-7 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Krüger Achim Institut für Molekulare Immunologie und Experimentelle Onkologie, Klinikum rechts der Isar der Technischen Universität München|, Ismaninger Str. 22, D-81675, München, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/11(2015-11-01), 1193-1201 0946-2716 93:11<1193 2015 93 109