caa a22 4500 605544077 CHVBK 20210128100929.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00109-015-1329-4 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1329-4 Bone metastasis and the metastatic niche [Elektronische Daten] [Guangwen Ren, Mark Esposito, Yibin Kang] The bone marrow has been long known to host a unique environment amenable to colonization by metastasizing tumor cells. Yet, the underlying molecular interactions within this specialized microenvironment which give rise to the high incidence of bone metastasis in breast and prostate cancer patients have long remained uncharacterized. With the recent description of the bone metastatic "niche,” considerable focus has been placed on understanding how the bone stroma contributes to each step of metastasis. Discoveries within this field have demonstrated that when cancer cells home to the niche in which hematopoietic and mesenchymal stem/progenitor cells normally reside, a bidirectional crosstalk emerges between the tumor cells and the bone metastatic stroma. This communication modulates every step of cancer cell metastasis to the bone, including the initial homing and seeding, formation of micrometastases, outgrowth of macrometastases, and the maintenance of long-term dormancy of disseminated tumor cells in the bone. In clinical practice, targeting the bone metastatic niche is evolving into a promising avenue for the prevention of bone metastatic relapse, therapeutic resistance, and other aspects of cancer progression. Here, we review the current knowledge concerning the role of the bone metastatic niche in bone metastasis. Springer-Verlag Berlin Heidelberg, 2015 Bone metastasis nationallicence Metastatic niche nationallicence Osteoblastic niche nationallicence Perivascular niche nationallicence Tumor dormancy nationallicence Hematopoiesis nationallicence Ren Guangwen Department of Molecular Biology, Princeton University, LTL255, Washington Road, 08544, Princeton, NJ, USA aut Esposito Mark Department of Molecular Biology, Princeton University, LTL255, Washington Road, 08544, Princeton, NJ, USA aut Kang Yibin Department of Molecular Biology, Princeton University, LTL255, Washington Road, 08544, Princeton, NJ, USA aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/11(2015-11-01), 1203-1212 0946-2716 93:11<1203 2015 93 109 https://doi.org/10.1007/s00109-015-1329-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1329-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ren Guangwen Department of Molecular Biology, Princeton University, LTL255, Washington Road, 08544, Princeton, NJ, USA aut NATIONALLICENCE 700 1- Esposito Mark Department of Molecular Biology, Princeton University, LTL255, Washington Road, 08544, Princeton, NJ, USA aut NATIONALLICENCE 700 1- Kang Yibin Department of Molecular Biology, Princeton University, LTL255, Washington Road, 08544, Princeton, NJ, USA aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/11(2015-11-01), 1203-1212 0946-2716 93:11<1203 2015 93 109