caa a22 4500 605544239 CHVBK 20210128100930.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10897-014-9755-y doi (NATIONALLICENCE)springer-10.1007/s10897-014-9755-y The Psychological Impact of Predictive Genetic Testing for Huntington′s Disease: A Systematic Review of the Literature [Elektronische Daten] [S Crozier, N Robertson, M Dale] Huntington′s disease (HD) is a neurodegenerative genetic condition for which a predictive genetic test by mutation analysis has been available since 1993. However, whilst revealing the future presence of the disease, testing may have an adverse psychological impact given that the disease is progressive, incurable and ultimately fatal. This review seeks to systematically explore the psychological impact of genetic testing for individuals undergoing pre-symptomatic mutation analysis. Three databases (Medline, PsycInfo and Scopus) were interrogated for studies utilising standardised measures to assess psychological impact following predictive genetic testing for HD. From 100 papers initially identified, eight articles were eligible for inclusion. Psychological impact of predictive genetic testing was not found to be associated with test result. No detrimental effect of predictive genetic testing on non-carriers was found, although the process was not found to be psychologically neutral. Fluctuation in levels of distress was found over time for carriers and non-carriers alike. Methodological weaknesses of published literature were identified, notably the needs of individuals not requesting genetic testing, as well as inadequate support for individuals registering elevated distress and declining post-test follow-up. Further assessment of these vulnerable individuals is warranted to establish the extent and type of future psychological support. National Society of Genetic Counselors, Inc., 2014 Genetic testing nationallicence Predictive testing nationallicence Huntington′s disease nationallicence Psychological impact nationallicence Systematic review nationallicence Crozier S. Department of Clinical Psychology, University of Leicester, 104 Regent Road, Leicester, UK aut Robertson N. Department of Clinical Psychology, University of Leicester, 104 Regent Road, Leicester, UK aut Dale M. Adult Mental Health Psychology, Leicestershire Partnership NHS Trust, Leicester, UK aut Journal of Genetic Counseling Springer US; http://www.springer-ny.com 24/1(2015-02-01), 29-39 1059-7700 24:1<29 2015 24 10897 https://doi.org/10.1007/s10897-014-9755-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10897-014-9755-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Crozier S. Department of Clinical Psychology, University of Leicester, 104 Regent Road, Leicester, UK aut NATIONALLICENCE 700 1- Robertson N. Department of Clinical Psychology, University of Leicester, 104 Regent Road, Leicester, UK aut NATIONALLICENCE 700 1- Dale M. Adult Mental Health Psychology, Leicestershire Partnership NHS Trust, Leicester, UK aut NATIONALLICENCE 773 0- Journal of Genetic Counseling Springer US; http://www.springer-ny.com 24/1(2015-02-01), 29-39 1059-7700 24:1<29 2015 24 10897