caa a22 4500 60554445X CHVBK 20210128100931.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10897-014-9769-5 doi (NATIONALLICENCE)springer-10.1007/s10897-014-9769-5 Applying Public Health Screening Criteria: How Does Universal Newborn Screening Compare to Universal Tumor Screening for Lynch Syndrome in Adults with Colorectal Cancer? [Elektronische Daten] [Deborah Cragun, Rita DeBate, Tuya Pal] Institutions have increasingly begun to adopt universal tumor screening (UTS) programs whereby tumors from all newly diagnosed patients with colorectal cancer (CRC) are screened to identify who should be offered germline testing for Lynch syndrome (the most common cause of hereditary CRC). Given limited information about the impact of universal screening programs to detect hereditary disease in adults, we apply criteria used to evaluate public health screening programs and compare and contrast UTS with universal newborn screening (NBS) for the purpose of examining ethical implications and anticipating potential outcomes of UTS. Both UTS and a core set of NBS conditions clearly meet most of the Wilson and Jungner screening criteria. However, many state NBS panels include additional conditions that do not meet several of these criteria, and there is currently insufficient data to confirm that UTS meets some of these criteria. Comparing UTS and NBS with regard to newer screening criteria raises additional issues that require attention for both UTS and NBS. Comparisons also highlight the importance of evaluating the implementation of genomic tests to ensure or improve their effectiveness at reducing morbidity and mortality while minimizing potential harms. National Society of Genetic Counselors, Inc., 2014 Public health genomics nationallicence Lynch syndrome nationallicence Newborn screening nationallicence Screening criteria nationallicence Tumor screening nationallicence Cragun Deborah Department of Cancer Epidemiology, Moffitt Cancer Center, 12902, Magnolia Drive, 33612, Tampa, FL, USA aut DeBate Rita Department of Community and Family Health, University of South Florida, Tampa, FL, USA aut Pal Tuya Department of Cancer Epidemiology, Moffitt Cancer Center, 12902, Magnolia Drive, 33612, Tampa, FL, USA aut Journal of Genetic Counseling Springer US; http://www.springer-ny.com 24/3(2015-06-01), 409-420 1059-7700 24:3<409 2015 24 10897 https://doi.org/10.1007/s10897-014-9769-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10897-014-9769-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cragun Deborah Department of Cancer Epidemiology, Moffitt Cancer Center, 12902, Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- DeBate Rita Department of Community and Family Health, University of South Florida, Tampa, FL, USA aut NATIONALLICENCE 700 1- Pal Tuya Department of Cancer Epidemiology, Moffitt Cancer Center, 12902, Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 773 0- Journal of Genetic Counseling Springer US; http://www.springer-ny.com 24/3(2015-06-01), 409-420 1059-7700 24:3<409 2015 24 10897