caa a22 4500 605544905 CHVBK 20210128100933.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10897-014-9803-7 doi (NATIONALLICENCE)springer-10.1007/s10897-014-9803-7 Personalized Medicine Through SNP Testing for Breast Cancer Risk: Clinical Implementation [Elektronische Daten] [Rebecca Howe, Talya Miron-Shatz, Yaniv Hanoch, Zehra Omer, Cristina O'Donoghue, Elissa Ozanne] Single nucleotide polymorphisms (SNPs) have the potential to improve personalized medicine in breast cancer care. As new SNPs are discovered, further enhancing risk classification, SNP testing may serve to complement family history and phenotypic risk factors when assessed in a clinical setting. SNP analysis is particularly relevant to high-risk women who may seek out such information to guide their decision-making around risk-reduction. However, little is known about how high-risk women may respond to SNP testing with regard to clinical decision-making. We examined high-risk women's interest in SNP testing for breast cancer risk through an online survey of hypothetical testing scenarios. Women stated their preferences for sharing test results and selected the most likely follow-up action they would pursue in each of the test result scenarios (above average and below average risk for breast cancer). Four hundred seventy-eight women participated. Most women (89%) did not know what a SNP was prior to the study. Once SNP testing was described, 75% were interested in SNP testing. Participants stated an interest in lifestyle interventions for risk-reduction and wanted to discuss their testing results with their doctor or a genetic counselor. Women are interested in SNP testing and are prepared to make lifestyle changes based on testing results. Women's preference for discussing testing results with a healthcare provider aligns with the current trend towards SNP testing in a clinical setting. National Society of Genetic Counselors, Inc., 2014 Breast cancer nationallicence Risk assessment nationallicence SNP testing nationallicence Decision making nationallicence Howe Rebecca Frank H. Netter MD School of Medicine, Quinnipiac University, North Haven, CT, USA aut Miron-Shatz Talya Center for Medical Decision Making, Ono Academic College, Kiryat Ono, Israel aut Hanoch Yaniv Department of Psychology, Plymouth University, Plymouth, UK aut Omer Zehra School of Medicine, University of Massachusetts, Worcester, MA, USA aut O'Donoghue Cristina Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA aut Ozanne Elissa Department of Surgery, University of California at San Francisco, San Francisco, CA, USA aut Journal of Genetic Counseling Springer US; http://www.springer-ny.com 24/5(2015-10-01), 744-751 1059-7700 24:5<744 2015 24 10897 https://doi.org/10.1007/s10897-014-9803-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10897-014-9803-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Howe Rebecca Frank H. Netter MD School of Medicine, Quinnipiac University, North Haven, CT, USA aut NATIONALLICENCE 700 1- Miron-Shatz Talya Center for Medical Decision Making, Ono Academic College, Kiryat Ono, Israel aut NATIONALLICENCE 700 1- Hanoch Yaniv Department of Psychology, Plymouth University, Plymouth, UK aut NATIONALLICENCE 700 1- Omer Zehra School of Medicine, University of Massachusetts, Worcester, MA, USA aut NATIONALLICENCE 700 1- O'Donoghue Cristina Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA aut NATIONALLICENCE 700 1- Ozanne Elissa Department of Surgery, University of California at San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Journal of Genetic Counseling Springer US; http://www.springer-ny.com 24/5(2015-10-01), 744-751 1059-7700 24:5<744 2015 24 10897