caa a22 4500 605545278 CHVBK 20210128100935.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00723-015-0670-7 doi (NATIONALLICENCE)springer-10.1007/s00723-015-0670-7 Comparative Analysis by Magnetic Resonance Imaging of Extracellular Space Diffusion and Interstitial Fluid Flow in the Rat Striatum and Thalamus [Elektronische Daten] [Long Zuo, Kai Li, Hongbin Han] Drug delivery to the brain remains a challenge due to the blood-brain barrier. Localized injection of drug therapies represents a promising alternative once the diffusion characteristics of different brain regions have been evaluated. Extracellular space diffusion and interstitial fluid flow of the striatum and thalamus in the rat brain were simultaneously compared using magnetic resonance imaging and the tracer gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA). The diffusion parameters, volume distribution, and half-life time were quantified. While there was extensive diffusion of Gd-DTPA in the striatum, Gd-DTPA was rapidly cleared and had a shorter half-life time in the thalamus. The increased clearance rate and shorter half-life of the tracer in the thalamus were associated with increased expression of Aquaporin-4. The tortuosity of the extracellular space did not show a statistically significant difference between the two regions examined. Our research provides a new reference for brain interstitial drug delivery to treat central nervous system diseases and a better understanding of the brain microenvironment. Springer-Verlag Wien, 2015 Zuo Long Department of Radiology, Peking University Third Hospital, 100191, Beijing, China aut Li Kai Department of Radiology, Beijing Jishuitan Hospital, 100035, Beijing, China aut Han Hongbin Department of Radiology, Peking University Third Hospital, 100191, Beijing, China aut Applied Magnetic Resonance Springer Vienna 46/6(2015-06-01), 623-632 0937-9347 46:6<623 2015 46 723 https://doi.org/10.1007/s00723-015-0670-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00723-015-0670-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zuo Long Department of Radiology, Peking University Third Hospital, 100191, Beijing, China aut NATIONALLICENCE 700 1- Li Kai Department of Radiology, Beijing Jishuitan Hospital, 100035, Beijing, China aut NATIONALLICENCE 700 1- Han Hongbin Department of Radiology, Peking University Third Hospital, 100191, Beijing, China aut NATIONALLICENCE 773 0- Applied Magnetic Resonance Springer Vienna 46/6(2015-06-01), 623-632 0937-9347 46:6<623 2015 46 723