caa a22 4500 605545308 CHVBK 20210128100935.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00723-015-0668-1 doi (NATIONALLICENCE)springer-10.1007/s00723-015-0668-1 Assessing Renal Ischemia/Reperfusion Injury in Mice Using Time-Dependent BOLD and DTI at 9.4T [Elektronische Daten] [Dong-Cheol Woo, Nayoung Kim, Do-Wan Lee, Youyol Song, Woo Shim, Yoonseok Choi, Chul-Woong Woo, Sang-Tae Kim, Jeong-Kon Kim, Kyungwon Kim, Hyun-Kwon Ha, Jin Lee] The primary goal of this study was to quantitatively assess regional changes in function and pathophysiological characteristics in renal ischemia/reperfusion (IR)-injured mice and compare data obtained at baseline and following injury. The second goal was to correlate blood oxygenation level-dependent (BOLD) and diffusion tensor imaging (DTI) data obtained in renal IR-injured mice at baseline using time-dependent scans. The analyses were conducted using a mouse model of IR injury. T2*, apparent diffusion coefficient (ADC), and fractional anisotropy (FA) values were acquired to pathophysiologically evaluate three renal regions. The T2* values obtained in the renal cortex and medulla demonstrated no significant differences between baseline and after IR injury. According to DTI results, ADC values in both renal regions were significantly lower at 0h, and then gradually increased within 48h. The FA values of both renal regions decreased at 0h, and then gradually increased by 8h after IR injury. BOLD and DTI correlations were not significant in renal cortex. However, significantly positive correlations were found between baseline and time-dependent data obtained from renal medulla of IR-injured kidneys. Our current findings suggest that magnetic resonance imaging could be used to obtain pathophysiological data from separate renal compartments in IR-injured mice. Hence, BOLD and DTI may also provide functional and pathophysiological data on allograft status following kidney transplant without the need to use a contrast agent. Springer-Verlag Wien, 2015 Woo Dong-Cheol MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut Kim Nayoung MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut Lee Do-Wan MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut Song Youyol MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut Shim Woo Department of Radiology, ASAN Medical Center, Seoul, South Korea aut Choi Yoonseok MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut Woo Chul-Woong MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut Kim Sang-Tae MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut Kim Jeong-Kon Department of Radiology, ASAN Medical Center, Seoul, South Korea aut Kim Kyungwon Department of Radiology, ASAN Medical Center, Seoul, South Korea aut Ha Hyun-Kwon Department of Radiology, ASAN Medical Center, Seoul, South Korea aut Lee Jin Department of Radiology, ASAN Medical Center, Seoul, South Korea aut Applied Magnetic Resonance Springer Vienna 46/6(2015-06-01), 709-722 0937-9347 46:6<709 2015 46 723 https://doi.org/10.1007/s00723-015-0668-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00723-015-0668-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Woo Dong-Cheol MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Nayoung MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Lee Do-Wan MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Song Youyol MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Shim Woo Department of Radiology, ASAN Medical Center, Seoul, South Korea aut NATIONALLICENCE 700 1- Choi Yoonseok MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Woo Chul-Woong MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Sang-Tae MR Core Laboratory, Asan Institute for Life Sciences, ASAN Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 138-736, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Jeong-Kon Department of Radiology, ASAN Medical Center, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Kyungwon Department of Radiology, ASAN Medical Center, Seoul, South Korea aut NATIONALLICENCE 700 1- Ha Hyun-Kwon Department of Radiology, ASAN Medical Center, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Jin Department of Radiology, ASAN Medical Center, Seoul, South Korea aut NATIONALLICENCE 773 0- Applied Magnetic Resonance Springer Vienna 46/6(2015-06-01), 709-722 0937-9347 46:6<709 2015 46 723