α-Synuclein and β-Amyloid form a Bridged Copper Complex
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| 024 | 7 | 0 | |a 10.1007/s00723-015-0662-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00723-015-0662-7 | ||
| 100 | 1 | |a Drew |D Simon |u Florey Department of Neuroscience and Mental Health, The University of Melbourne, 3010, Parkville, VIC, Australia |4 aut | |
| 245 | 1 | 0 | |a α-Synuclein and β-Amyloid form a Bridged Copper Complex |h [Elektronische Daten] |c [Simon Drew] |
| 520 | 3 | |a The deposition of insoluble β-amyloid (Aβ) peptide into extracellular senile plaques is a pathological hallmarkof Alzheimer's disease. Fragmented α-synuclein (αSyn) and a relatively high concentration of Cu2+ ions are found within amyloid deposits. Both Aβ and αSyn bind Cu2+ with an apparent dissociation constant in the sub-nanomolar range at physiological pH, fuelling speculation that deleterious redox chemistry and metal-mediated protein misfolding may contribute to disease progression. Binary Cu(Aβ) and Cu(αSyn) complexes have been extensively studied, although the Cu2+ coordination of heterogeneous mixtures of Aβ and αSyn has yet to be characterised. This study used synthetic N-terminal fragments Aβ1-16 and αSyn1-56 to reveal a new Cu(αSyn)(Aβ) coordination mode anchored upon a 5,6-membered chelate supplied by Met1-Asp2 of αSyn, with the fourth equatorial ligand being supplied by a His side chain of Aβ. | |
| 540 | |a Springer-Verlag Wien, 2015 | ||
| 773 | 0 | |t Applied Magnetic Resonance |d Springer Vienna |g 46/9(2015-09-01), 1041-1052 |x 0937-9347 |q 46:9<1041 |1 2015 |2 46 |o 723 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00723-015-0662-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00723-015-0662-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 100 |E 1- |a Drew |D Simon |u Florey Department of Neuroscience and Mental Health, The University of Melbourne, 3010, Parkville, VIC, Australia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Magnetic Resonance |d Springer Vienna |g 46/9(2015-09-01), 1041-1052 |x 0937-9347 |q 46:9<1041 |1 2015 |2 46 |o 723 | ||