Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging
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| 024 | 7 | 0 | |a 10.1007/s00723-015-0674-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00723-015-0674-3 | ||
| 245 | 0 | 0 | |a Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging |h [Elektronische Daten] |c [Irina Agafonova, Taisiya Moskovkina] |
| 520 | 3 | |a The action of tryptanthrin, a known natural alkaloid, a potent inhibitor of cyclooxygenase COX-2 and 5-lipoxygenase, was studied in a model of dextran sodium sulfate (DSS)-induced mouse colitis by magnetic resonance imaging (MRI). It was shown that the intra-ventricular treatment with tryptanthrin suspensions or emulsion at a dose of 25 mg/kg effectively diminishes lethality at experimental groups and normalizes morphometric parameters of intestine in the treated animals. MR imaging confirmed anti-inflammatory effect of this alkaloid and its capability to decrease the size of bowel walls in animals with colitis. | |
| 540 | |a Springer-Verlag Wien, 2015 | ||
| 700 | 1 | |a Agafonova |D Irina |u G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 690022, Vladivostok, Russia |4 aut | |
| 700 | 1 | |a Moskovkina |D Taisiya |u Far East Federal University, 690000, Vladivostok, Russia |4 aut | |
| 773 | 0 | |t Applied Magnetic Resonance |d Springer Vienna |g 46/7(2015-07-01), 781-791 |x 0937-9347 |q 46:7<781 |1 2015 |2 46 |o 723 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00723-015-0674-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00723-015-0674-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Agafonova |D Irina |u G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 690022, Vladivostok, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Moskovkina |D Taisiya |u Far East Federal University, 690000, Vladivostok, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Magnetic Resonance |d Springer Vienna |g 46/7(2015-07-01), 781-791 |x 0937-9347 |q 46:7<781 |1 2015 |2 46 |o 723 | ||