caa a22 4500 605545480 CHVBK 20210128100936.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00723-015-0674-3 doi (NATIONALLICENCE)springer-10.1007/s00723-015-0674-3 Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging [Elektronische Daten] [Irina Agafonova, Taisiya Moskovkina] The action of tryptanthrin, a known natural alkaloid, a potent inhibitor of cyclooxygenase COX-2 and 5-lipoxygenase, was studied in a model of dextran sodium sulfate (DSS)-induced mouse colitis by magnetic resonance imaging (MRI). It was shown that the intra-ventricular treatment with tryptanthrin suspensions or emulsion at a dose of 25 mg/kg effectively diminishes lethality at experimental groups and normalizes morphometric parameters of intestine in the treated animals. MR imaging confirmed anti-inflammatory effect of this alkaloid and its capability to decrease the size of bowel walls in animals with colitis. Springer-Verlag Wien, 2015 Agafonova Irina G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 690022, Vladivostok, Russia aut Moskovkina Taisiya Far East Federal University, 690000, Vladivostok, Russia aut Applied Magnetic Resonance Springer Vienna 46/7(2015-07-01), 781-791 0937-9347 46:7<781 2015 46 723 https://doi.org/10.1007/s00723-015-0674-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00723-015-0674-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Agafonova Irina G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 690022, Vladivostok, Russia aut NATIONALLICENCE 700 1- Moskovkina Taisiya Far East Federal University, 690000, Vladivostok, Russia aut NATIONALLICENCE 773 0- Applied Magnetic Resonance Springer Vienna 46/7(2015-07-01), 781-791 0937-9347 46:7<781 2015 46 723