Gadolinium-Loaded Viral Capsids as Magnetic Resonance Imaging Contrast Agents
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| 024 | 7 | 0 | |a 10.1007/s00723-014-0639-y |2 doi |
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| 245 | 0 | 0 | |a Gadolinium-Loaded Viral Capsids as Magnetic Resonance Imaging Contrast Agents |h [Elektronische Daten] |c [Robert Usselman, Shefah Qazi, Priyanka Aggarwal, Sandra Eaton, Gareth Eaton, Stephen Russek, Trevor Douglas] |
| 520 | 3 | |a Polymeric nanohybrid P22 virus capsids were used as templates for high density Gd3+ loading to explore magnetic field-dependent (0.5-7.0 T) proton relaxivity. The field-dependence of relaxivity by the spatially constrained Gd3+ in the capsids was similar when either the loading of the capsids or the concentration of capsids was varied. The ionic longitudinal relaxivity, r 1, decreased from 25-32mM−1 s−1 at 0.5T to 6-10mM−1s−1 at 7T. The ionic transverse relaxivity, r 2, increased from 28-37mM−1s−1 at 0.5T to 39-50mM−1s−1 at 7T. The r 2/r 1 ratio increased linearly with increasing magnetic field from about 1 at 0.5T, which is typical of T 1 contrast agents, to 5-8 at 7T, which is approaching the ratios for T 2 contrast agents. Increases in electron paramagnetic resonance line widths at 80 and 150K and higher microwave powers required for signal saturation indicate enhanced Gd3+ electron spin relaxation rates for the Gd3+-loaded capsids than for low concentration Gd3+. The largest r 2/r 1 at 7T was for the highest cage loading, which suggests that Gd3+-Gd3+ interactions within the capsid enhance r 2 more than r 1. | |
| 540 | |a Springer-Verlag Wien, 2015 | ||
| 700 | 1 | |a Usselman |D Robert |u Electromagnetics Division, National Institute of Standards and Technology, 80305, Boulder, CO, USA |4 aut | |
| 700 | 1 | |a Qazi |D Shefah |u Department of Chemistry and Biochemistry, Montana State University, 59717, Bozeman, MT, USA |4 aut | |
| 700 | 1 | |a Aggarwal |D Priyanka |u Department of Chemistry and Biochemistry, University of Denver, 80208, Denver, CO, USA |4 aut | |
| 700 | 1 | |a Eaton |D Sandra |u Department of Chemistry and Biochemistry, University of Denver, 80208, Denver, CO, USA |4 aut | |
| 700 | 1 | |a Eaton |D Gareth |u Department of Chemistry and Biochemistry, University of Denver, 80208, Denver, CO, USA |4 aut | |
| 700 | 1 | |a Russek |D Stephen |u Electromagnetics Division, National Institute of Standards and Technology, 80305, Boulder, CO, USA |4 aut | |
| 700 | 1 | |a Douglas |D Trevor |u Department of Chemistry, Indiana University, 47405, Bloomington, IN, USA |4 aut | |
| 773 | 0 | |t Applied Magnetic Resonance |d Springer Vienna |g 46/3(2015-03-01), 349-355 |x 0937-9347 |q 46:3<349 |1 2015 |2 46 |o 723 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00723-014-0639-y |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00723-014-0639-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Usselman |D Robert |u Electromagnetics Division, National Institute of Standards and Technology, 80305, Boulder, CO, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Qazi |D Shefah |u Department of Chemistry and Biochemistry, Montana State University, 59717, Bozeman, MT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aggarwal |D Priyanka |u Department of Chemistry and Biochemistry, University of Denver, 80208, Denver, CO, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Eaton |D Sandra |u Department of Chemistry and Biochemistry, University of Denver, 80208, Denver, CO, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Eaton |D Gareth |u Department of Chemistry and Biochemistry, University of Denver, 80208, Denver, CO, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Russek |D Stephen |u Electromagnetics Division, National Institute of Standards and Technology, 80305, Boulder, CO, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Douglas |D Trevor |u Department of Chemistry, Indiana University, 47405, Bloomington, IN, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Magnetic Resonance |d Springer Vienna |g 46/3(2015-03-01), 349-355 |x 0937-9347 |q 46:3<349 |1 2015 |2 46 |o 723 | ||