Intracerebral Antioxidant Ability of Neonatal Rats After Acute Hypoxic-Ischemic Brain Injury Estimated Using the Brain Homogenate-ESR Method
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| 024 | 7 | 0 | |a 10.1007/s00723-015-0710-3 |2 doi |
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| 245 | 0 | 0 | |a Intracerebral Antioxidant Ability of Neonatal Rats After Acute Hypoxic-Ischemic Brain Injury Estimated Using the Brain Homogenate-ESR Method |h [Elektronische Daten] |c [Akira Nakajima, Li Yang, Emiko Matsuda, Ayako Nagano, Hiroshi Sameshima, Tsuyomu Ikenoue] |
| 520 | 3 | |a The intracerebral antioxidant ability of neonatal rats after acute hypoxic-ischemic (HI) brain injury was estimated using the brain homogenate-ESR method after intraperitoneal injection of 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl, blood-brain-barrier permeable stable cyclic nitroxide. Seven-day-old Wistar rats were subjected to a modified Levine's procedure for producing HI brain injury. The rats 7days after HI insult were ranked in severe, mild and normal groups based on their brain damage. The severe brain damage was observed with high probability. The intracerebral antioxidant ability of the normal and mild groups was same as that of the control rats. On the other hand, the antioxidant ability in the ligated side of the cerebral hemisphere of the severe group was significantly lower than that of the control rats. The HI insult resulted in the oxidative stress and the insufficient supply of the endogenous antioxidants, which caused the significant decrease in the intracerebral antioxidant ability. The brain homogenate-ESR method can be easily conducted for a large number of neonatal rats at regular time intervals, which indicates the usefulness of the method to evaluate the intracerebral antioxidant ability of neonatal rats. | |
| 540 | |a Springer-Verlag Wien, 2015 | ||
| 700 | 1 | |a Nakajima |D Akira |u Department of Biotechnology, Frontier Science Research Center, University of Miyazaki, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | |
| 700 | 1 | |a Yang |D Li |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | |
| 700 | 1 | |a Matsuda |D Emiko |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | |
| 700 | 1 | |a Nagano |D Ayako |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | |
| 700 | 1 | |a Sameshima |D Hiroshi |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | |
| 700 | 1 | |a Ikenoue |D Tsuyomu |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | |
| 773 | 0 | |t Applied Magnetic Resonance |d Springer Vienna |g 46/10(2015-10-01), 1079-1088 |x 0937-9347 |q 46:10<1079 |1 2015 |2 46 |o 723 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00723-015-0710-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00723-015-0710-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nakajima |D Akira |u Department of Biotechnology, Frontier Science Research Center, University of Miyazaki, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yang |D Li |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Matsuda |D Emiko |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nagano |D Ayako |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sameshima |D Hiroshi |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ikenoue |D Tsuyomu |u Section of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, 889-1692, Kiyotake, Miyazaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Magnetic Resonance |d Springer Vienna |g 46/10(2015-10-01), 1079-1088 |x 0937-9347 |q 46:10<1079 |1 2015 |2 46 |o 723 | ||