caa a22 4500 60554607X CHVBK 20210128100939.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00723-015-0654-7 doi (NATIONALLICENCE)springer-10.1007/s00723-015-0654-7 The Use of the Levenberg-Marquardt and Variable Projection Curve-Fitting Algorithm in Intravoxel Incoherent Motion Method for DW-MRI Data Analysis [Elektronische Daten] [Roberta Fusco, Mario Sansone, Antonella Petrillo] The objective of this study was to evaluate the performances of different algorithms for diffusion parameters estimation in intravoxel incoherent motion method for diffusion-weighted magnetic resonance imaging (DW-MRI) data analysis. Traditionally, the method of non-linear least squares analysis by means of Levenberg-Marquardt algorithms has been used to estimate the parameters obtained from exponential decay data. In this study, we evaluated the Variable Projection curve-fitting algorithm and the performance of two non-linear regression methods when single and multiple starting points were used. Analysis was done on simulation data to which different amounts of Gaussian noise had been added. The performance of two non-linear regression methods was compared using the residual sum of squares and the number of failures in data fitting. We conclude that the VarPro algorithm is superior tothe LM algorithm for curve fitting in intravoxel incoherent motion method for DW-MRI data analysis. Springer-Verlag Wien, 2015 Fusco Roberta Division of Radiology, Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori Fondazione Giovanni Pascale, IRCCS, via Mariano Semmola, 80131, Naples, Italy aut Sansone Mario Department of Electrical Engineering and Information Technologies, University "Federico II” of Naples, via Claudio, 21, 80132, Naples, Italy aut Petrillo Antonella Division of Radiology, Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori Fondazione Giovanni Pascale, IRCCS, via Mariano Semmola, 80131, Naples, Italy aut Applied Magnetic Resonance Springer Vienna 46/5(2015-05-01), 551-558 0937-9347 46:5<551 2015 46 723 https://doi.org/10.1007/s00723-015-0654-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00723-015-0654-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fusco Roberta Division of Radiology, Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori Fondazione Giovanni Pascale, IRCCS, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Sansone Mario Department of Electrical Engineering and Information Technologies, University "Federico II” of Naples, via Claudio, 21, 80132, Naples, Italy aut NATIONALLICENCE 700 1- Petrillo Antonella Division of Radiology, Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori Fondazione Giovanni Pascale, IRCCS, via Mariano Semmola, 80131, Naples, Italy aut NATIONALLICENCE 773 0- Applied Magnetic Resonance Springer Vienna 46/5(2015-05-01), 551-558 0937-9347 46:5<551 2015 46 723