Photoinduced Interaction of Atorvastatin with Acetophenone
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| 024 | 7 | 0 | |a 10.1007/s00723-014-0632-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00723-014-0632-5 | ||
| 245 | 0 | 0 | |a Photoinduced Interaction of Atorvastatin with Acetophenone |h [Elektronische Daten] |c [Anna Schlotgauer, Svetlana Petrova, Alexander Kruppa, Tatyana Leshina] |
| 520 | 3 | |a The one of the most often prescribed preparation in the world, atorvastatin (ATR), lipid—lowering agent and antioxidant, is used for the prevention and treatment of atherosclerosis. At that the nature of its antioxidant activity is still unknown. This work presents the first example of the elementary mechanisms of ATR red-ox reactions, including the single electron transfer and the interaction with short-lived ketyl radicals. ATR reactivity has been investigated by means of the method of time-resolved chemically induced dynamic nuclear polarization (TR-CIDNP), nuclear magnetic resonance spectroscopy, ultraviolet spectroscopy, high-performance liquid chromatography, mass spectrometry and quantum chemical (DFT) calculations. To study the interaction of ATR with ketyl radicals in the solution acetophenone photolysis was used as a model reaction. It was shown that carbon atoms, belonging to the secondary alcohol groups of the dihydroxyheptane acid anion, are the reaction centers of ATR molecule in reactions with ketyl radicals. Because all statins have this fragment, one can expect that other statins could react with free radicals by this route. Thus, the proposed mechanism might be the one among several channels providing statins antioxidant activity. | |
| 540 | |a Springer-Verlag Wien, 2015 | ||
| 700 | 1 | |a Schlotgauer |D Anna |u Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Petrova |D Svetlana |u Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Kruppa |D Alexander |u Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Leshina |D Tatyana |u Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia |4 aut | |
| 773 | 0 | |t Applied Magnetic Resonance |d Springer Vienna |g 46/2(2015-02-01), 219-237 |x 0937-9347 |q 46:2<219 |1 2015 |2 46 |o 723 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00723-014-0632-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00723-014-0632-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schlotgauer |D Anna |u Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Petrova |D Svetlana |u Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kruppa |D Alexander |u Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Leshina |D Tatyana |u Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Magnetic Resonance |d Springer Vienna |g 46/2(2015-02-01), 219-237 |x 0937-9347 |q 46:2<219 |1 2015 |2 46 |o 723 | ||