caa a22 4500 605546169 CHVBK 20210128100939.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00723-014-0632-5 doi (NATIONALLICENCE)springer-10.1007/s00723-014-0632-5 Photoinduced Interaction of Atorvastatin with Acetophenone [Elektronische Daten] [Anna Schlotgauer, Svetlana Petrova, Alexander Kruppa, Tatyana Leshina] The one of the most often prescribed preparation in the world, atorvastatin (ATR), lipid—lowering agent and antioxidant, is used for the prevention and treatment of atherosclerosis. At that the nature of its antioxidant activity is still unknown. This work presents the first example of the elementary mechanisms of ATR red-ox reactions, including the single electron transfer and the interaction with short-lived ketyl radicals. ATR reactivity has been investigated by means of the method of time-resolved chemically induced dynamic nuclear polarization (TR-CIDNP), nuclear magnetic resonance spectroscopy, ultraviolet spectroscopy, high-performance liquid chromatography, mass spectrometry and quantum chemical (DFT) calculations. To study the interaction of ATR with ketyl radicals in the solution acetophenone photolysis was used as a model reaction. It was shown that carbon atoms, belonging to the secondary alcohol groups of the dihydroxyheptane acid anion, are the reaction centers of ATR molecule in reactions with ketyl radicals. Because all statins have this fragment, one can expect that other statins could react with free radicals by this route. Thus, the proposed mechanism might be the one among several channels providing statins antioxidant activity. Springer-Verlag Wien, 2015 Schlotgauer Anna Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia aut Petrova Svetlana Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia aut Kruppa Alexander Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia aut Leshina Tatyana Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia aut Applied Magnetic Resonance Springer Vienna 46/2(2015-02-01), 219-237 0937-9347 46:2<219 2015 46 723 https://doi.org/10.1007/s00723-014-0632-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00723-014-0632-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schlotgauer Anna Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Petrova Svetlana Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Kruppa Alexander Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Leshina Tatyana Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Institutskaya st., 3, 630090, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Applied Magnetic Resonance Springer Vienna 46/2(2015-02-01), 219-237 0937-9347 46:2<219 2015 46 723