caa a22 4500 605546231 CHVBK 20210128100939.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00723-015-0720-1 doi (NATIONALLICENCE)springer-10.1007/s00723-015-0720-1 Design and simulation of a dual-tuned 1H/23Na birdcage coil for MRS studies in human calf [Elektronische Daten] [Giulio Giovannetti, Giuseppe Valvano, Giorgio Virgili, Massimo Giannoni, Alessandra Flori, Francesca Frijia, Daniele De Marchi, Valentina Hartwig, Luigi Landini, Giovanni Aquaro, Alessandro Pingitore] Sodium magnetic resonance is a very promising tool for achieving biochemical information on tissue viability, cell integrity and function in quantitative and noninvasive manner. Although it has already been applied in vivo in most human tissues, the low detectable sodium signal gives rise to technological limitations in terms of data quality when using clinical scanners. The design of dedicated coils capable of providing large field of view with high signal-to-noise ratio data is a requirement for quantifying tissutal sodium. This work describes design, simulation, construction and test of a dual-tuned 1H/23Na birdcage coil for magnetic resonance (MR) studies in human calf performed with a 3-T MR scanner. Coil simulation was performed using an electromagnetic solver based on finite-difference time-domain (FDTD) method, while the design included matching, tuning and trap circuits' realization for 1H/23Na decoupling. Successively, a prototype of the coil was built and tested at workbench, for quality factors, Q ratio measurements and 1H/23Na channels' decoupling evaluation. Finally, the coil was employed in a 3-Tesla scanner for acquiring MR data. The results are presented as signal profiles for both coil channels extracted from the phantom chemical shift image and with in vivo imaging performed on human calfs. The designed dual-tuned coil provided good decoupling between H and Na channels, by permitting to maximize the homogeneity of the magnetic field at both the frequencies of interest. Moreover, the simulations accuracy was demonstrated by good agreement between the theoretical and experimental coil signal profiles. Springer-Verlag Wien, 2015 Giovannetti Giulio Institute of Clinical Physiology (I.F.C.), National Council of Research (C.N.R.), via G. Moruzzi 1, S. Cataldo, 56124, Pisa, Italy aut Valvano Giuseppe Department of Information Engineering, University of Pisa, via Diotisalvi 2, 56126, Pisa, Italy aut Virgili Giorgio West Systems s.r.l., Viale Donato Giannotti 24, 56126, Firenze, Italy aut Giannoni Massimo Institute of Clinical Physiology (I.F.C.), National Council of Research (C.N.R.), via G. Moruzzi 1, S. Cataldo, 56124, Pisa, Italy aut Flori Alessandra Fondazione G. Monasterio CNR - Regione Toscana, via G. Moruzzi 1, 56124, Pisa, Italy aut Frijia Francesca Fondazione G. Monasterio CNR - Regione Toscana, via G. Moruzzi 1, 56124, Pisa, Italy aut De Marchi Daniele Fondazione G. Monasterio CNR - Regione Toscana, via G. Moruzzi 1, 56124, Pisa, Italy aut Hartwig Valentina Institute of Clinical Physiology (I.F.C.), National Council of Research (C.N.R.), via G. Moruzzi 1, S. Cataldo, 56124, Pisa, Italy aut Landini Luigi Department of Information Engineering, University of Pisa, via Diotisalvi 2, 56126, Pisa, Italy aut Aquaro Giovanni Fondazione G. Monasterio CNR - Regione Toscana, via G. Moruzzi 1, 56124, Pisa, Italy aut Pingitore Alessandro Institute of Clinical Physiology (I.F.C.), National Council of Research (C.N.R.), via G. Moruzzi 1, S. Cataldo, 56124, Pisa, Italy aut Applied Magnetic Resonance Springer Vienna 46/11(2015-11-01), 1221-1238 0937-9347 46:11<1221 2015 46 723 https://doi.org/10.1007/s00723-015-0720-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00723-015-0720-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Giovannetti Giulio Institute of Clinical Physiology (I.F.C.), National Council of Research (C.N.R.), via G. Moruzzi 1, S. Cataldo, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Valvano Giuseppe Department of Information Engineering, University of Pisa, via Diotisalvi 2, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Virgili Giorgio West Systems s.r.l., Viale Donato Giannotti 24, 56126, Firenze, Italy aut NATIONALLICENCE 700 1- Giannoni Massimo Institute of Clinical Physiology (I.F.C.), National Council of Research (C.N.R.), via G. Moruzzi 1, S. Cataldo, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Flori Alessandra Fondazione G. Monasterio CNR - Regione Toscana, via G. Moruzzi 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Frijia Francesca Fondazione G. Monasterio CNR - Regione Toscana, via G. Moruzzi 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- De Marchi Daniele Fondazione G. Monasterio CNR - Regione Toscana, via G. Moruzzi 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Hartwig Valentina Institute of Clinical Physiology (I.F.C.), National Council of Research (C.N.R.), via G. Moruzzi 1, S. Cataldo, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Landini Luigi Department of Information Engineering, University of Pisa, via Diotisalvi 2, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Aquaro Giovanni Fondazione G. Monasterio CNR - Regione Toscana, via G. Moruzzi 1, 56124, Pisa, Italy aut NATIONALLICENCE 700 1- Pingitore Alessandro Institute of Clinical Physiology (I.F.C.), National Council of Research (C.N.R.), via G. Moruzzi 1, S. Cataldo, 56124, Pisa, Italy aut NATIONALLICENCE 773 0- Applied Magnetic Resonance Springer Vienna 46/11(2015-11-01), 1221-1238 0937-9347 46:11<1221 2015 46 723