caa a22 4500 606153799 CHVBK 20210128100555.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s11121-014-0528-5 doi (NATIONALLICENCE)springer-10.1007/s11121-014-0528-5 Sample Size for Joint Testing of Indirect Effects [Elektronische Daten] [Eric Vittinghoff, Torsten Neilands] This paper presents methods to calculate sample size for evaluating mediation by joint testing of both links in an indirect pathway from exposure to mediator to outcome. Calculations rely on simulations of the underlying data structure, with testing of the two links performed under the simplifying assumption that the two test statistics are asymptotically independent. Simulations show that the proposed methods are accurate. Continuous and binary exposures and mediators, as well as continuous, binary, count, and survival outcomes are accommodated, along with over-dispersion of count outcomes, design effects, and confounding of the exposure-mediator and mediator-outcome relationships. An illustrative example is provided, and a documented R program implementing the calculations is available online. Society for Prevention Research, 2014 Mediation nationallicence Indirect pathway nationallicence Sample size nationallicence Power nationallicence Generalized linear models nationallicence Vittinghoff Eric Department of Epidemiology and Biostatistics, University of California San Francisco, 550 16th Street, 2nd Floor, 94158, San Francisco, CA, USA aut Neilands Torsten Department of Medicine, Center for AIDS Prevention Studies, University of California San Francisco, 550 16th Street, 3rd Floor, 94158, San Francisco, CA, USA aut Prevention Science Springer US; http://www.springer-ny.com 16/8(2015-11-01), 1128-1135 1389-4986 16:8<1128 2015 16 11121 https://doi.org/10.1007/s11121-014-0528-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11121-014-0528-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vittinghoff Eric Department of Epidemiology and Biostatistics, University of California San Francisco, 550 16th Street, 2nd Floor, 94158, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Neilands Torsten Department of Medicine, Center for AIDS Prevention Studies, University of California San Francisco, 550 16th Street, 3rd Floor, 94158, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Prevention Science Springer US; http://www.springer-ny.com 16/8(2015-11-01), 1128-1135 1389-4986 16:8<1128 2015 16 11121