caa a22 4500 606154353 CHVBK 20210128100558.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10561-014-9440-2 doi (NATIONALLICENCE)springer-10.1007/s10561-014-9440-2 Mesenchymal stem cells for chronic wounds therapy [Elektronische Daten] [Peter Zahorec, Jan Koller, Lubos Danisovic, Martin Bohac] Wound healing is a complex process that involves interaction of soluble mediators, extracellular matrix and infiltrating blood cells. Chronic and non-healing skin defects contribute significantly to morbidity and mortality of many patients. Recently, despite the current medical progress, the chronic and non-healing wounds still represent a serious medical problem. In many cases, conventional therapeutic approaches, such as dermal substitutes and growth factor therapy failed and do not produce the expected results, patients are exposed to a high risk of infection, sepsis or amputation. For that reason clinicians and researchers are forced to searching for alternative methods to induce healing process which may result into complete wound closure. Mesenchymal stem cells (MSCs) represent a unique tool of tissue engineering and regenerative medicine and a promising therapeutic strategy. Due to their unique biological properties, MSCs seem to be the perspective modality method for these patients. Many preclinical and clinical studies suggest the possibility of using these cells in tissue regeneration, healing acute and chronic wounds and scar remodelling. The objective of the present review is to summarize the current information and preclinical data about MSCs, their biological characteristics and mode of action during regenerative and healing processes, as well as their clinical application in chronic wounds treatment. Springer Science+Business Media Dordrecht, 2014 Chronic wounds nationallicence Mesenchymal stem cells nationallicence Differentiation nationallicence Paracrine signalling nationallicence Regeneration nationallicence Zahorec Peter Department of Burns and Reconstructive Surgery, Faculty of Medicine, Comenius University in Bratislava, Pazitkova 4, 821 01, Bratislava, Slovakia aut Koller Jan Department of Burns and Reconstructive Surgery, Faculty of Medicine, Comenius University in Bratislava, Pazitkova 4, 821 01, Bratislava, Slovakia aut Danisovic Lubos Faculty of Medicine, Institute of Medical Biology, Genetics and Clinical Genetics, Comenius University in Bratislava, Sasinkova 4, 811 08, Bratislava, Slovakia aut Bohac Martin University Hospital, Bratislava, Slovakia aut Cell and Tissue Banking Springer Netherlands 16/1(2015-03-01), 19-26 1389-9333 16:1<19 2015 16 10561 https://doi.org/10.1007/s10561-014-9440-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10561-014-9440-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zahorec Peter Department of Burns and Reconstructive Surgery, Faculty of Medicine, Comenius University in Bratislava, Pazitkova 4, 821 01, Bratislava, Slovakia aut NATIONALLICENCE 700 1- Koller Jan Department of Burns and Reconstructive Surgery, Faculty of Medicine, Comenius University in Bratislava, Pazitkova 4, 821 01, Bratislava, Slovakia aut NATIONALLICENCE 700 1- Danisovic Lubos Faculty of Medicine, Institute of Medical Biology, Genetics and Clinical Genetics, Comenius University in Bratislava, Sasinkova 4, 811 08, Bratislava, Slovakia aut NATIONALLICENCE 700 1- Bohac Martin University Hospital, Bratislava, Slovakia aut NATIONALLICENCE 773 0- Cell and Tissue Banking Springer Netherlands 16/1(2015-03-01), 19-26 1389-9333 16:1<19 2015 16 10561