caa a22 4500 606154477 CHVBK 20210128100558.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10561-014-9450-0 doi (NATIONALLICENCE)springer-10.1007/s10561-014-9450-0 Results from a horizon scan on risks associated with transplantation of human organs, tissues and cells: from donor to patient [Elektronische Daten] [C. Herberts, M. Park, J. Pot, C. de Vries] The successful transplantation of human materials such as organs, tissues and cells into patients does not only depend on the benefits, but also on the mitigation of risks. To gain insight into recent publications on risks associated with the process of transferring human materials from donor to recipient we performed a horizon scan by reviewing scientific literature and news websites of 2011 on this subject. We found there is ample information on how extended donor criteria, such as donor age, affect the survival rates of organs or patients. Interestingly, gender mismatch does not appear to be a major risk factor in organ rejection. Data on risks of donor tumor transmission was very scarce; however, risk categories for various tumor types have been suggested. In order to avoid rejection, a lot of research is directed towards engineering tissues from a patient's own tissues and cells. Some but not all of these developments have reached the clinic. Developments in the field of stem cell therapy are rapid. However, many hurdles are yet to be overcome before these cells can be applied on a large scale in the clinic. The processes leading to genetic abnormalities in cells differentiated from stem cells need to be identified in order to avoid transplantation of aberrant cells. New insights have been obtained on storage and preservation of human materials, a critical step for success of their clinical use. Likewise, quality management systems have been shown to improve the quality and safety of human materials used for transplantation. Springer Science+Business Media Dordrecht, 2014 Medical use nationallicence Human organ nationallicence Human tissue nationallicence Human cells nationallicence Risk nationallicence Procurement nationallicence Processing nationallicence Donation nationallicence Herberts C. Section on Pharmacology, Toxicology and Biotechnology, Medicines Evaluation Board (MEB), P.O. Box 8275, 3503 RG, Utrecht, The Netherlands aut Park M. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut Pot J. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut de Vries C. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut Cell and Tissue Banking Springer Netherlands 16/1(2015-03-01), 1-17 1389-9333 16:1<1 2015 16 10561 https://doi.org/10.1007/s10561-014-9450-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10561-014-9450-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Herberts C. Section on Pharmacology, Toxicology and Biotechnology, Medicines Evaluation Board (MEB), P.O. Box 8275, 3503 RG, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Park M. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Pot J. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- de Vries C. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 773 0- Cell and Tissue Banking Springer Netherlands 16/1(2015-03-01), 1-17 1389-9333 16:1<1 2015 16 10561