caa a22 4500 606154809 CHVBK 20210128100600.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10561-015-9510-0 doi (NATIONALLICENCE)springer-10.1007/s10561-015-9510-0 Preparation of porous PLA/DBM composite biomaterials and experimental research of repair rabbit radius segmental bone defect [Elektronische Daten] [Yumin Zhang, Jianru Wang, Jue Wang, Xiaojun Niu, Jianchun Liu, Lan Gao, Xiaoyan Zhai, Kaibo Chu] Bone substitutes are used in wide range of orthopaedic application. An ideal bone substitute should exhibit superior osteoinductive and osteoconductive properties. Neither bio-derived materials nor synthetic materials can meet the needs of an ideal bone substitute. Preparation of composite materials is a promising way to improve properties of biomaterial. In this study, the porous poly lactic acid (PLA)/demineralized bone matrix (DBM) composite biomaterials prepared by supercritical CO2 technique were implanted to repair rabbit radius segmental bone defect. By comparing with PLA and bone autograft, the X-ray result and histological analysis showed the repair effect of PLA/DBM porous composite materials is significantly better than that of the PLA group and the blank control group, and is similar to autologous bone. The PLA/DBM can promote the healing of bone defects and can be used as a kind of ideal alternative materials to repair bone defects. Springer Science+Business Media Dordrecht, 2015 Composite biomaterials nationallicence Bone allograft nationallicence Poly lactic acid nationallicence Supercritical CO2 nationallicence Zhang Yumin Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut Wang Jianru Shanxi Medical University, Taiyuan, Shanxi, China aut Wang Jue Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut Niu Xiaojun Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut Liu Jianchun Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut Gao Lan Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut Zhai Xiaoyan Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut Chu Kaibo Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut Cell and Tissue Banking Springer Netherlands 16/4(2015-12-01), 615-622 1389-9333 16:4<615 2015 16 10561 https://doi.org/10.1007/s10561-015-9510-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10561-015-9510-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Yumin Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut NATIONALLICENCE 700 1- Wang Jianru Shanxi Medical University, Taiyuan, Shanxi, China aut NATIONALLICENCE 700 1- Wang Jue Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut NATIONALLICENCE 700 1- Niu Xiaojun Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut NATIONALLICENCE 700 1- Liu Jianchun Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut NATIONALLICENCE 700 1- Gao Lan Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut NATIONALLICENCE 700 1- Zhai Xiaoyan Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut NATIONALLICENCE 700 1- Chu Kaibo Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China aut NATIONALLICENCE 773 0- Cell and Tissue Banking Springer Netherlands 16/4(2015-12-01), 615-622 1389-9333 16:4<615 2015 16 10561