caa a22 4500 606154833 CHVBK 20210128100600.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10561-015-9501-1 doi (NATIONALLICENCE)springer-10.1007/s10561-015-9501-1 A retrospective study on annual evaluation of radiation processing for frozen bone allografts complying to quality system requirements [Elektronische Daten] [Saravana Ramalingam, Suhaili Mohd, Sharifah Samsuddin, N. Min, Norimah Yusof, Azura Mansor] Bone allografts have been used widely to fill up essential void in orthopaedic surgeries. The benefit of using allografts to replace and reconstruct musculoskeletal injuries, fractures or disease has obtained overwhelming acceptance from orthopaedic surgeons worldwide. However, bacterial infection and disease transmission through bone allograft transplantation have always been a significant issue. Sterilization by radiation is an effective method to eliminate unwanted microorganisms thus assist in preventing life threatening allograft associated infections. Femoral heads procured from living donors and long bones (femur and tibia) procured from cadaveric donors were sterilized at 25kGy in compliance with international standard ISO 11137. According to quality requirements, all records of bone banking were evaluated annually. This retrospective study was carried out on annual evaluation of radiation records from 1998 until 2012. The minimum doses absorbed by the bones were ranging from 25.3 to 38.2kGy while the absorbed maximum doses were from 25.4 to 42.3kGy. All the bones supplied by our UMMC Bone Bank were sterile at the required minimum dose of 25kGy. Our analysis on dose variation showed that the dose uniformity ratios in 37 irradiated boxes of 31 radiation batches were in the range of 1.003-1.251, which indicated the doses were well distributed. Springer Science+Business Media Dordrecht, 2015 Bone allograft nationallicence Gamma irradiation nationallicence Ceric/cerous nationallicence Absorbed dose nationallicence Dose uniformity ratio (DUR) nationallicence Ramalingam Saravana UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut Mohd Suhaili UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut Samsuddin Sharifah UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut Min N. UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut Yusof Norimah UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut Mansor Azura UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut Cell and Tissue Banking Springer Netherlands 16/4(2015-12-01), 545-552 1389-9333 16:4<545 2015 16 10561 https://doi.org/10.1007/s10561-015-9501-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10561-015-9501-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ramalingam Saravana UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut NATIONALLICENCE 700 1- Mohd Suhaili UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut NATIONALLICENCE 700 1- Samsuddin Sharifah UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut NATIONALLICENCE 700 1- Min N. UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut NATIONALLICENCE 700 1- Yusof Norimah UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut NATIONALLICENCE 700 1- Mansor Azura UMMC Bone Bank, Department of Orthopaedic Surgery, Faculty of Medicine, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia aut NATIONALLICENCE 773 0- Cell and Tissue Banking Springer Netherlands 16/4(2015-12-01), 545-552 1389-9333 16:4<545 2015 16 10561