caa a22 4500 606154868 CHVBK 20210128100600.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10561-015-9497-6 doi (NATIONALLICENCE)springer-10.1007/s10561-015-9497-6 The risk of transmitting cutaneous malignancy through skin transplantation: a literature-based risk assessment [Elektronische Daten] [Sarah Bosma, Marja Van Wijk, Cornelia Richters, Hilde Beele] According to the European Union Tissues and Cells Directives donation of tissue is contraindicated in the presence of or a previous history of malignant disease, with the exception of cutaneous basal cell carcinoma. Skin cancer is the most common cancer. Due to ultraviolet light exposure and increasing life expectancy an increasing prevalence of malignant or premalignant skin lesions is observed, which may result in a decline of the availability of skin for transplantation. A risk assessment based on published studies and expert opinion was performed in order to investigate the risk of transmitting malignant or premalignant skin lesions through tissue transplantation, and more particular through skin transplantation. The scarcity of data concerning cancer transmission in tissue transplantation was challenging. Circumstantial evidence, available for organ transplantation, was used to develop the following policy proposal for skin transplantation and cutaneous tumours. Malignant melanoma is an absolute contraindication for the donation of skin and also of other tissues, whereas, non-lesional skin and other tissues of a donor with non-melanoma skin cancer (basal cell and squamous cell carcinoma) or with a premalignant skin lesion can be considered for transplantation. The above mentioned protocol proposal might serve as a prototype for analogous protocols for non-cutaneous malignancies. Springer Science+Business Media Dordrecht, 2015 Tissue transplantation nationallicence Cutaneous malignancies nationallicence Transmission nationallicence Risk assessment nationallicence Guidelines nationallicence Bosma Sarah Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium aut Van Wijk Marja BISLIFE Foundation, Leiden, The Netherlands aut Richters Cornelia Euro Tissue Bank, Division Euro Skin Bank, Beverwijk, The Netherlands aut Beele Hilde Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium aut Cell and Tissue Banking Springer Netherlands 16/4(2015-12-01), 503-512 1389-9333 16:4<503 2015 16 10561 https://doi.org/10.1007/s10561-015-9497-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10561-015-9497-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bosma Sarah Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium aut NATIONALLICENCE 700 1- Van Wijk Marja BISLIFE Foundation, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Richters Cornelia Euro Tissue Bank, Division Euro Skin Bank, Beverwijk, The Netherlands aut NATIONALLICENCE 700 1- Beele Hilde Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium aut NATIONALLICENCE 773 0- Cell and Tissue Banking Springer Netherlands 16/4(2015-12-01), 503-512 1389-9333 16:4<503 2015 16 10561