caa a22 4500 606154884 CHVBK 20210128100600.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10561-015-9502-0 doi (NATIONALLICENCE)springer-10.1007/s10561-015-9502-0 Validation of cold chain shipping environment for transport of allografts as part of a human tissue bank returns policy [Elektronische Daten] [P. Rooney, M. Eagle, J. Kearney] Human tissue is shipped to surgeons in the UK in either a freeze-dried or frozen state. To ensure quality and safety of the tissue, frozen tissue must be shipped in insulated containers such that tissue is maintained at an appropriate temperature. UK Blood Transfusion Service regulations state "Transportation systems must be validated to show maintenance of the required storage temperature” and also state that frozen, non-cryopreserved tissue "must be transported at −20°C or lower” (Guidelines for the Blood Transfusion Services in the United Kingdom, 8th Edn. 2013). To maintain an expiry date for frozen tissue longer than 6months, the tissue must be maintained at a temperature of −40°C or below. The objective of this study was to evaluate and validate the capability of a commercially available insulated polystyrene carton (XPL10), packed with dry ice, to maintain tissue temperature below −40°C. Tissue temperature of a single frozen femoral head or a single frozen Achilles tendon, was recorded over a 4-day period at 37°C, inside a XPL10 carton with dry ice as refrigerant. The data demonstrate that at 37°C, the XPL10 carton with 9.5kg of dry ice maintained femoral head and tendon tissue temperature below −55°C for at least 48h; tissue temperature did not rise above −40°C until at least 70h. Data also indicated that at a storage temperature lower than 37°C, tissue temperature was maintained for longer periods. Springer Science+Business Media Dordrecht, 2015 Low temperature nationallicence Container nationallicence Transport nationallicence Achilles tendon nationallicence Femoral head nationallicence Allograft nationallicence Rooney P. NHSBT, Tissue Services R&D, 14 Estuary Banks, Speke, L24 8RB, Liverpool, UK aut Eagle M. NHSBT, Tissue Services R&D, 14 Estuary Banks, Speke, L24 8RB, Liverpool, UK aut Kearney J. NHSBT, Tissue Services R&D, 14 Estuary Banks, Speke, L24 8RB, Liverpool, UK aut Cell and Tissue Banking Springer Netherlands 16/4(2015-12-01), 553-558 1389-9333 16:4<553 2015 16 10561 https://doi.org/10.1007/s10561-015-9502-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10561-015-9502-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rooney P. NHSBT, Tissue Services R&D, 14 Estuary Banks, Speke, L24 8RB, Liverpool, UK aut NATIONALLICENCE 700 1- Eagle M. NHSBT, Tissue Services R&D, 14 Estuary Banks, Speke, L24 8RB, Liverpool, UK aut NATIONALLICENCE 700 1- Kearney J. NHSBT, Tissue Services R&D, 14 Estuary Banks, Speke, L24 8RB, Liverpool, UK aut NATIONALLICENCE 773 0- Cell and Tissue Banking Springer Netherlands 16/4(2015-12-01), 553-558 1389-9333 16:4<553 2015 16 10561