caa a22 4500 606155015 CHVBK 20210128100601.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10561-014-9470-9 doi (NATIONALLICENCE)springer-10.1007/s10561-014-9470-9 Lyophilized xenograft: a case series of histological analysis of biopsies [Elektronische Daten] [Tiango Ribeiro, Caroline Coussirat, Fernando Pagnussato, Cristiano Diesel, Fernando Macedo, Carlos Macedo, Carlos Galia] The reconstruction of an acetabular bone defect is one of the most important aspects of revision total hip arthroplasty surgery. It can be done by the use of grafts. Therefore, many kinds of grafts may be used and lyophilized xenograft is an alternative example. The purpose of the study was to evaluate the histological findings of lyophilized bovine xenografts used in previous total hip arthroplasty revision surgery. A case series was carried out from July 2000 to April 2013 with the approval of the Hospital Ethics Committee. Fourteen subjects were analyzed. Of these, 64.3% were female. The average age of the patients was 52.36±18.55. Neoformed bone was present in 85.7% of subjects, and constituted 61.79% of the total bone matrix area. The diagnosis of xenograft absorption was present in 12 subjects. A strong inverse correlation between the percentage of neoformed bone and the percentage of xenograft in the total bone matrix by analysis of biopsies was found by the Pearson test (p=0.001). No inflammatory response was found in the clinical status of the patients or in the histological analysis. Lyophilized bovine xenograft shown to be safe until the present moment, with acceptable results. Most of the cases presented new bone formation as expected (considered values greater than 30%) and for this reason the xenograft has proven to be an osteoconductive compatible scaffold/trellis for the bone ingrowth. Therefore, it can be considered an alternative to other bone grafts in the treatment of bone loss. Springer Science+Business Media Dordrecht, 2014 Freeze drying nationallicence Xenograft nationallicence Biopsy nationallicence Transplantation nationallicence Heterologous nationallicence Lophilized nationallicence Bovine bone nationallicence Total hip arthroplasty nationallicence Revision arthroplasty nationallicence Ribeiro Tiango Programa de Pós-Graduação em Medicina, Cirurgia - Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2350, CEP 90035-903, Porto Alegre, Rio Grande do Sul (RS), Brazil aut Coussirat Caroline Banco de Multitecidos do Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul (RS), Brazil aut Pagnussato Fernando Banco de Multitecidos do Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul (RS), Brazil aut Diesel Cristiano Programa de Pós-Graduação em Medicina, Cirurgia - Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2350, CEP 90035-903, Porto Alegre, Rio Grande do Sul (RS), Brazil aut Macedo Fernando Serviço de Ortopedia e Traumatologia do Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul (RS), Brazil aut Macedo Carlos Serviço de Ortopedia e Traumatologia do Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul (RS), Brazil aut Galia Carlos Programa de Pós-Graduação em Medicina, Cirurgia - Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2350, CEP 90035-903, Porto Alegre, Rio Grande do Sul (RS), Brazil aut Cell and Tissue Banking Springer Netherlands 16/2(2015-06-01), 227-233 1389-9333 16:2<227 2015 16 10561 https://doi.org/10.1007/s10561-014-9470-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10561-014-9470-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ribeiro Tiango Programa de Pós-Graduação em Medicina, Cirurgia - Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2350, CEP 90035-903, Porto Alegre, Rio Grande do Sul (RS), Brazil aut NATIONALLICENCE 700 1- Coussirat Caroline Banco de Multitecidos do Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul (RS), Brazil aut NATIONALLICENCE 700 1- Pagnussato Fernando Banco de Multitecidos do Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul (RS), Brazil aut NATIONALLICENCE 700 1- Diesel Cristiano Programa de Pós-Graduação em Medicina, Cirurgia - Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2350, CEP 90035-903, Porto Alegre, Rio Grande do Sul (RS), Brazil aut NATIONALLICENCE 700 1- Macedo Fernando Serviço de Ortopedia e Traumatologia do Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul (RS), Brazil aut NATIONALLICENCE 700 1- Macedo Carlos Serviço de Ortopedia e Traumatologia do Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul (RS), Brazil aut NATIONALLICENCE 700 1- Galia Carlos Programa de Pós-Graduação em Medicina, Cirurgia - Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2350, CEP 90035-903, Porto Alegre, Rio Grande do Sul (RS), Brazil aut NATIONALLICENCE 773 0- Cell and Tissue Banking Springer Netherlands 16/2(2015-06-01), 227-233 1389-9333 16:2<227 2015 16 10561