caa a22 4500 606155163 CHVBK 20210128100602.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10096-014-2212-x doi (NATIONALLICENCE)springer-10.1007/s10096-014-2212-x CMV in the gut: a critical review of CMV detection in the immunocompetent host with colitis [Elektronische Daten] [A. Goodman, C. Murray, J. Watkins, P. Griffiths, D. Webster] As scientific techniques for the detection of cytomegalovirus (CMV) improve, we are able to detect small amounts of CMV in the mucosal wall. As clinicians, we are unsure how to interpret the results of this novel test. There is controversy in the literature as to the significance of the detection of CMV in the gut. Whilst the importance of CMV and reactivation of the virus is clear in those patients such as allograft recipients with established immune compromise, the role is less clear in patients with less damaged immune systems. We explore whether the detection of CMV in such cases influences outcome and how it should be optimally managed. We discuss the optimal management of such cases, according to current guidelines, with a review of the literature. The Author(s), 2014 Goodman A. Department of Infection and Immunity, University College London, Cruciform Building, Gower Street, WC1E 6BT, London, UK aut Murray C. Department of Gastroenterology, Royal Free London NHS Foundation Trust, NW3 2QG, London, UK aut Watkins J. Department of Cellular Pathology, Royal Free London NHS Foundation Trust, NW3 2QG, London, UK aut Griffiths P. Centre for Virology, University College London Medical School, Rowland Hill Street, NW3 2PF, London, UK aut Webster D. Centre for Virology, University College London Medical School, Rowland Hill Street, NW3 2PF, London, UK aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 13-18 0934-9723 34:1<13 2015 34 10096 https://doi.org/10.1007/s10096-014-2212-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2212-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goodman A. Department of Infection and Immunity, University College London, Cruciform Building, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Murray C. Department of Gastroenterology, Royal Free London NHS Foundation Trust, NW3 2QG, London, UK aut NATIONALLICENCE 700 1- Watkins J. Department of Cellular Pathology, Royal Free London NHS Foundation Trust, NW3 2QG, London, UK aut NATIONALLICENCE 700 1- Griffiths P. Centre for Virology, University College London Medical School, Rowland Hill Street, NW3 2PF, London, UK aut NATIONALLICENCE 700 1- Webster D. Centre for Virology, University College London Medical School, Rowland Hill Street, NW3 2PF, London, UK aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 13-18 0934-9723 34:1<13 2015 34 10096