caa a22 4500 606155228 CHVBK 20210128100602.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10096-014-2217-5 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2217-5 Evaluation of two commercially available rapid diagnostic tests for Lyme borreliosis [Elektronische Daten] [P. Smit, S. Kurkela, M. Kuusi, O. Vapalahti] The diagnosis of Lyme disease is very complicated and a single diagnostic method cannot exclude infection. We assessed the performance of two commercially available Borrelia burgdorferi rapid diagnostic tests (RDT) in comparison to multiple laboratory-based diagnostic assays using specimens with a gradually increasing probability of Borrelia infection. Based on 200 specimens, the analytical sensitivities for IgG and IgM were 18 and 23% for the Lyme RDT and 24 and 32% for the Borreliose Complete RDT. The sensitivity for detecting diagnosed Lyme borreliosis cases was low (26% Lyme RDT and 32% with the Borreliose Complete RDT respectively), whereas the specificity was good (85% Lyme RDT and 88% Borreliose Complete). Based on this evaluation, the performance of RDTs in detecting Lyme borreliosis appeared to be below that of laboratory-based diagnostics. Springer-Verlag Berlin Heidelberg, 2014 Smit P. European Program for Public Health Microbiology Training, European Centre for Disease Prevention and Control, Stockholm, Sweden aut Kurkela S. Faculty of Medicine, University of Helsinki, Helsinki, Finland aut Kuusi M. Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland aut Vapalahti O. Faculty of Medicine, University of Helsinki, Helsinki, Finland aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 109-113 0934-9723 34:1<109 2015 34 10096 https://doi.org/10.1007/s10096-014-2217-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2217-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Smit P. European Program for Public Health Microbiology Training, European Centre for Disease Prevention and Control, Stockholm, Sweden aut NATIONALLICENCE 700 1- Kurkela S. Faculty of Medicine, University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 700 1- Kuusi M. Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland aut NATIONALLICENCE 700 1- Vapalahti O. Faculty of Medicine, University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 109-113 0934-9723 34:1<109 2015 34 10096