caa a22 4500 606155295 CHVBK 20210128100602.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10096-014-2206-8 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2206-8 High seroprevalence of human herpesvirus type 8 in patients with hepatocellular carcinoma [Elektronische Daten] [C.-C. Su, K.-C. Tseng, M.-N. Lin, T.-C. Hsieh, T.-Y. Chu] Cirrhosis patients have immunologic insufficiency and a high seroprevalence of human herpesvirus type 8 (HHV-8). Nearly all hepatocellular carcinoma (HCC) patients are cirrhotic and have immunoabnormalities. This study aimed to assess the HHV-8 seroprevalence and hemograms in HCC patients. Blood samples from 95 HCC patients, 95 age-, sex-, and Child-Pugh class-matched cirrhotics, and 95 age- and sex-matched healthy controls were analyzed for anti-HHV-8 antibodies, HHV-8 DNA, and lymphocyte, monocyte, and platelet counts. HCC patients had lower lymphocyte and platelet counts and a higher monocyte count than the healthy controls (each p < 0.0001). HCC patients, and particularly those with a severe Child-Pugh class, had higher platelet counts than the corresponding cirrhosis patients (p = 0.003 and 0.002, respectively). HHV-8 seropositivity and antibody titers in HCC patients were comparable with values in cirrhosis patients and were much higher than in controls (both p < 0.0001). HCC patients, but not cirrhosis patients, had a higher prevalence of high anti-HHV-8 antibody titers (≥1:160) than healthy controls (p = 0.003). HCC patients with lymphopenia or thrombocytopenia had lower HHV-8 seropositivity than those without lymphopenia and thrombocytopenia (p = 0.04 and 0.01, respectively). One each of HCC and cirrhosis patients were positive for HHV-8 DNA. HCC patients seemed to suffer from less severe or shorter duration of portal hypertension compared with Child-Pugh class-matched cirrhosis patients. HCC patients had a high HHV-8 seroprevalence, which seemed to be inversely associated with lymphopenia and thrombocytopenia. Springer-Verlag Berlin Heidelberg, 2014 Su C.-C Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan aut Tseng K.-C School of Medicine, Tzu Chi University, Hualien, Taiwan aut Lin M.-N Department of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan aut Hsieh T.-C Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan aut Chu T.-Y Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 55-62 0934-9723 34:1<55 2015 34 10096 https://doi.org/10.1007/s10096-014-2206-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2206-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Su C.-C Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan aut NATIONALLICENCE 700 1- Tseng K.-C School of Medicine, Tzu Chi University, Hualien, Taiwan aut NATIONALLICENCE 700 1- Lin M.-N Department of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan aut NATIONALLICENCE 700 1- Hsieh T.-C Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan aut NATIONALLICENCE 700 1- Chu T.-Y Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 55-62 0934-9723 34:1<55 2015 34 10096