caa a22 4500 60615535X CHVBK 20210128100603.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10096-014-2207-7 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2207-7 Helicobacter pylori infection and the risk of acute coronary syndrome: a nationwide retrospective cohort study [Elektronische Daten] [C.-Y. Lai, T.-Y. Yang, C.-L. Lin, C.-H. Kao] Helicobacter pylori infection (HPI) imposes substantial social costs and is of major etiological importance in peptic ulcer disease, gastric cancer, and accelerated cardiovascular diseases. This study determined the risk of acute coronary syndrome (ACS) associated with HPI in a nationwide retrospective cohort study. By using the Taiwan National Health Insurance Research Database (NHIRD), we identified patients diagnosed with HPI from 1998 to 2010. In addition, we randomly selected non-HPI controls frequency-matched by age, sex, and index year from the general population free of HPI. The risk of ACS was analyzed using Cox proportional hazards regression models in which sex, age, and comorbidities were included as variables. We identified 17,075 participants for the HPI group and selected 68,300 participants for the comparison group. The incidence rates were increased in the patients in the HPI group compared with those in the comparison group. Overall, the HPI patients exhibited a 1.93-fold high crude hazard ratio for ACS, and a 1.48-fold adjusted hazard ratio after age, sex, and comorbidities were adjusted. However, the overall adjusted hazard ratio of ACS increased with increasing age with a 3.11 to 8.24 adjusted hazard ratio among the various age groups. Several comorbidities, such as diabetes, hyperlipidemia, and COPD exhibited synergistic effects for ACS risk. We determined a significant association between ACS and comorbidities and provide evidence to encourage clinicians to observe ACS-related comorbidities. Springer-Verlag Berlin Heidelberg, 2014 Lai C.-Y Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan aut Yang T.-Y Molecular and Genomic Epidemiology Center, China Medical University Hospital, China Medical University, Taichung, Taiwan aut Lin C.-L Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan aut Kao C.-H Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 69-74 0934-9723 34:1<69 2015 34 10096 https://doi.org/10.1007/s10096-014-2207-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2207-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lai C.-Y Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Yang T.-Y Molecular and Genomic Epidemiology Center, China Medical University Hospital, China Medical University, Taichung, Taiwan aut NATIONALLICENCE 700 1- Lin C.-L Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Kao C.-H Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 69-74 0934-9723 34:1<69 2015 34 10096