caa a22 4500 606155384 CHVBK 20210128100603.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10096-014-2213-9 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2213-9 Influence of HLA-DRB alleles on haemorrhagic fever with renal syndrome in a Chinese Han population in Hubei Province, China [Elektronische Daten] [N. Zhu, F. Luo, Q. Chen, N. Li, H. Xiong, Y. Feng, Z. Yang, W. Hou] Specific human leucocyte antigen (HLA) alleles are considered a genetic risk factor for the progression of haemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses. The aim of this study was to establish whether HLA-DRB alleles are associated with the severity of HFRS caused by different types of hantaviruses in a Chinese Han population from Hubei Province of central China. Twenty-two specific HLA-DRB alleles were analysed by sequence-specific primer-polymerase chain reaction (SSP-PCR) in 100 HFRS patients and 213 healthy volunteers. Associations of HLA-DRB alleles with the severity and clinical parameters of HFRS caused by Hantaan virus (HTNV) or Seoul virus (SEOV) infection were evaluated. Six alleles (HLA-DRB1*0401-0411, HLA-DRB1*1001, HLA-DRB1*1101-1105, HLA-DRB1*1201-1202, HLA-DRB1*1305 and DRB5*0101-0201) demonstrated strong associations with HFRS caused by HTNV and SEOV infections. Further comparison of these HLA-DRB1 allele frequencies between HFRS patients with differing severities and healthy controls demonstrated that the HLA-DRB1*0401-0411, HLA-DRB1*1001 and DRB1*1305 alleles were more frequent in the moderate course of HTNV-infected HFRS. Meanwhile, the DRB1*1101-1105 allele was more frequently observed in the severe course of HTNV-infected HFRS. We also found that the HLA-DRB1*1201-1202 allele frequency was higher in the moderate course of SEOV-infected HFRS, whereas the DRB5*0101-0201 allele may play a protective role in moderate HFRS caused by both HTNV and SEOV infections. These results provide evidence of the influence of HLA-DRB on the severity of HFRS and confirm the effect of HLA-DRB on HFRS during different types of hantavirus infection in a Chinese Han population in Hubei Province, China. Springer-Verlag Berlin Heidelberg, 2014 Zhu N. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut Luo F. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut Chen Q. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut Li N. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut Xiong H. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut Feng Y. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut Yang Z. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut Hou W. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 187-195 0934-9723 34:1<187 2015 34 10096 https://doi.org/10.1007/s10096-014-2213-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2213-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu N. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut NATIONALLICENCE 700 1- Luo F. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut NATIONALLICENCE 700 1- Chen Q. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut NATIONALLICENCE 700 1- Li N. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut NATIONALLICENCE 700 1- Xiong H. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut NATIONALLICENCE 700 1- Feng Y. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut NATIONALLICENCE 700 1- Yang Z. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut NATIONALLICENCE 700 1- Hou W. State Key Laboratory of Virology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, 185 Donghu Road, 430071, Wuhan, China aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/1(2015-01-01), 187-195 0934-9723 34:1<187 2015 34 10096