caa a22 4500 606155430 CHVBK 20210128100603.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10096-015-2326-9 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2326-9 Genital Mycoplasma infections and their resistance phenotypes in an African setting [Elektronische Daten] [L. Kouegnigan Rerambiah, J.-C. Ndong, S. Medzegue, M. Elisee-Ndam, J. Djoba Siawaya] We investigated the antimicrobial susceptibilities of mycoplasmas in Gabonese men and women. A total of 1,332 men and women were included in the study. Sperm, urine, ureteral or vaginal swabs were collected from the subjects. Mycoplasmas identification and antimicrobial susceptibility to azithromycin, clarithromycin, erythromycin, josamycin, pristinamycin, doxycycline, tetracycline, ofloxacin and ciprofloxacin were tested using the Mycoplasma IST 2 kit. 794 subjects were positive for Mycoplasma. Respectively, 1.6 % and 82.24% of subjects were singly infected with M. hominis and Ureaplasma urealyticum and 15.87% had a mixed infection. M. hominis isolates were resistant to erythromycin and had an intermediate (I) to resistant (R) profile to azithromycin and clarithromycin. 84.6% of M. hominis strains were sensitive (S) to josamycin and pristinamycin. 30.8 % and 92.3% of M. hominis strains were sensitive to tetracycline and doxycycline, respectively. 76.9 and 84.6% of M. hominis isolates were sensitive to ciprofloxacin and ofloxacin, respectively. The sensitivity rates of U. urealyticum strains were 45.23 %, 47.7 %, 63.84 %, 90.8 % and 92% for azithromycin, erythromycin, clarithromycin, pristinamycin and josamycin, respectively. U. urealyticum strains showed 62.2 % and 79.7% sensitivity to tetracycline and doxycycline, respectively. The resistance rates to azithromycin, clarithromycin and erythromycin for samples with mixed infection were 72.8 %, 84.7 % and 85.6%, respectively. Josamycin and pristinamycin were 81.5% effective on samples with mixed infection. The sensitivity rates of samples with mixed infection to tetracycline, doxycycline, ciprofloxacin and ofloxacin were 32 %, 69.6 %, 8.9 % and 18.5%, respectively. Sub-Saharan Africa needs to use antibiotics rationally, as falling to do so would compromise the management of infectious diseases. Springer-Verlag Berlin Heidelberg, 2015 Kouegnigan Rerambiah L. Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut Ndong J.-C Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut Medzegue S. Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut Elisee-Ndam M. Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut Djoba Siawaya J. Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1087-1090 0934-9723 34:6<1087 2015 34 10096 https://doi.org/10.1007/s10096-015-2326-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2326-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kouegnigan Rerambiah L. Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut NATIONALLICENCE 700 1- Ndong J.-C Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut NATIONALLICENCE 700 1- Medzegue S. Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut NATIONALLICENCE 700 1- Elisee-Ndam M. Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut NATIONALLICENCE 700 1- Djoba Siawaya J. Unité des Recherche et de Diagnostic Spécialisé, Laboratoire National de Santé Publique, Avenue Felix Eboué, BP 10736, Libreville, Gabon aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1087-1090 0934-9723 34:6<1087 2015 34 10096