caa a22 4500 606155473 CHVBK 20210128100603.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10096-015-2342-9 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2342-9 Distribution of pilus islands and alpha-like protein genes of group B Streptococcus colonized in pregnant women in Beijing, China [Elektronische Daten] [B. Lu, D. Wang, H. Zhou, F. Zhu, D. Li, S. Zhang, Y. Shi, Y. Cui, L. Huang, H. Wu] Group B Streptococcus (GBS) is one of the major pathogens of severe newborn sepsis and meningitis. Understanding its regional molecular epidemiology is helpful for regulating efficient prevention practice. A total of 160 GBS strains were collected from colonized pregnant women in six hospital settings in Beijing, China. Polymerase chain reaction (PCR) assays were used to identify the pilus island (PI), alp genes profiling of the alpha-like protein family, and capsular polysaccharide (cps) serotyping. The clonal relationships between strains were investigated using multilocus sequence typing (MLST). All isolates carried at least one pilus island. The most frequently detected pilus island was PI-2a alone (70 isolates, 43.8%). The most prevalent alp gene was rib (60 isolates, 37.5%). Moreover, a strong association was noted between alp genes, serotyping, and pilus island profiles. The GBS isolates under study hinted similar molecular epidemical characteristics in Beijing to those reported worldwide, but having their regional distributional features. Springer-Verlag Berlin Heidelberg, 2015 Lu B. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut Wang D. National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, 102206, Beijing, China aut Zhou H. National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, 102206, Beijing, China aut Zhu F. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut Li D. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut Zhang S. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut Shi Y. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut Cui Y. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut Huang L. Department of Laboratory Medicine, First Hospital, Peking University, 100034, Beijing, China aut Wu H. BGI Tianjin, 300308, Tianjin, China aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1173-1179 0934-9723 34:6<1173 2015 34 10096 https://doi.org/10.1007/s10096-015-2342-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2342-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lu B. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Wang D. National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, 102206, Beijing, China aut NATIONALLICENCE 700 1- Zhou H. National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, 102206, Beijing, China aut NATIONALLICENCE 700 1- Zhu F. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Li D. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhang S. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Shi Y. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Cui Y. Department of Laboratory Medicine, Civil Aviation General Hospital, No. 1 Gaojing Street, Chaoyang District, 100123, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Huang L. Department of Laboratory Medicine, First Hospital, Peking University, 100034, Beijing, China aut NATIONALLICENCE 700 1- Wu H. BGI Tianjin, 300308, Tianjin, China aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1173-1179 0934-9723 34:6<1173 2015 34 10096