caa a22 4500 606155481 CHVBK 20210128100603.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10096-015-2339-4 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2339-4 Prevalence of anti-rubella, anti-measles and anti-mumps IgG antibodies in neonates and pregnant women in Catalonia (Spain) in 2013: susceptibility to measles increased from 2003 to 2013 [Elektronische Daten] [P. Plans, F. de Ory, M. Campins, E. Álvarez, T. Payà, E. Guisasola, C. Compte, K. Vellbé, C. Sánchez, M. Lozano, I. Aran, A. Bonmatí, R. Carreras, M. Jané, L. Cabero] Non-immune neonates and non-immune pregnant women are at risk of developing rubella, measles and mumps infections, including congenital rubella syndrome. We describe the seroepidemiology of measles, mumps and rubella (MMR) in neonates and pregnant women in Catalonia (Spain). Anti-rubella, anti-measles and anti-mumps serum IgG titres were assessed using enzyme-linked immunosorbent assay (ELISA) tests in 353 cord blood samples from neonates of a representative sample of pregnant women obtained in 2013. The prevalence of protective antibody titres in neonates was 96% for rubella IgG (≥8IU/ml), 90% for measles IgG (>300IU/ml) and 84% for mumps IgG (>460 EU/ml). Slightly lower prevalences of protective IgG titres, as estimated from the cord blood titres, were found in pregnant women: 95% for rubella IgG, 89% for measles IgG and 81% for mumps IgG. The anti-measles and anti-mumps IgG titres and the prevalences of protective IgG titres against measles and mumps increased significantly (p < 0.001) with maternal age. The prevalence of protective anti-measles IgG titres decreased by 7% [odds ratio (OR) = 0.15, p < 0.001), the prevalence of protective anti-rubella IgG titres increased by 3% (OR = 1.80, p < 0.05) and the MMR vaccination coverage (during childhood) in pregnant women increased by 54% (OR = 2.09, p < 0.001) from 2003 to 2013. We recommend to develop an MMR prevention programme in women of childbearing age based on mass MMR vaccination or MMR screening and vaccination of susceptible women to increase immunity levels against MMR. Springer-Verlag Berlin Heidelberg, 2015 Plans P. Public Health Agency of Catalonia, Department of Health of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain aut de Ory F. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain aut Campins M. Preventive Medicine and Epidemiology Service, Hospital Vall d'Hebron of Barcelona, Barcelona, Spain aut Álvarez E. Obstetrics Service, Hospital Josep Trueta of Girona, Girona, Spain aut Payà T. Gynaecology and Obstetrics Service, Hospital del Mar of Barcelona, Barcelona, Spain aut Guisasola E. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain aut Compte C. Obstetrics Service, Hospital Josep Trueta of Girona, Girona, Spain aut Vellbé K. Gynaecology and Obstetrics Service, Hospital del Mar of Barcelona, Barcelona, Spain aut Sánchez C. Obstetrics Service, Hospital Vall d'Hebron of Barcelona, Barcelona, Spain aut Lozano M. Obstetrics Service, Hospital Vall d'Hebron of Barcelona, Barcelona, Spain aut Aran I. Gynaecology and Obstetrics Service, Hospital del Mar of Barcelona, Barcelona, Spain aut Bonmatí A. Obstetrics Service, Hospital Josep Trueta of Girona, Girona, Spain aut Carreras R. Gynaecology and Obstetrics Service, Hospital del Mar of Barcelona, Barcelona, Spain aut Jané M. Public Health Agency of Catalonia, Department of Health of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain aut Cabero L. Obstetrics Service, Hospital Vall d'Hebron of Barcelona, Barcelona, Spain aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1161-1171 0934-9723 34:6<1161 2015 34 10096 https://doi.org/10.1007/s10096-015-2339-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2339-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Plans P. Public Health Agency of Catalonia, Department of Health of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain aut NATIONALLICENCE 700 1- de Ory F. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain aut NATIONALLICENCE 700 1- Campins M. Preventive Medicine and Epidemiology Service, Hospital Vall d'Hebron of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Álvarez E. Obstetrics Service, Hospital Josep Trueta of Girona, Girona, Spain aut NATIONALLICENCE 700 1- Payà T. Gynaecology and Obstetrics Service, Hospital del Mar of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Guisasola E. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain aut NATIONALLICENCE 700 1- Compte C. Obstetrics Service, Hospital Josep Trueta of Girona, Girona, Spain aut NATIONALLICENCE 700 1- Vellbé K. Gynaecology and Obstetrics Service, Hospital del Mar of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Sánchez C. Obstetrics Service, Hospital Vall d'Hebron of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Lozano M. Obstetrics Service, Hospital Vall d'Hebron of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Aran I. Gynaecology and Obstetrics Service, Hospital del Mar of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Bonmatí A. Obstetrics Service, Hospital Josep Trueta of Girona, Girona, Spain aut NATIONALLICENCE 700 1- Carreras R. Gynaecology and Obstetrics Service, Hospital del Mar of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Jané M. Public Health Agency of Catalonia, Department of Health of Catalonia, Roc Boronat 83-95, 008005, Barcelona, Spain aut NATIONALLICENCE 700 1- Cabero L. Obstetrics Service, Hospital Vall d'Hebron of Barcelona, Barcelona, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1161-1171 0934-9723 34:6<1161 2015 34 10096