caa a22 4500 606155546 CHVBK 20210128100604.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10096-015-2330-0 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2330-0 Safety and effectiveness of home intravenous antibiotic therapy for multidrug-resistant bacterial infections [Elektronische Daten] [A. Mujal, J. Sola, M. Hernandez, M.-A. Villarino, M.-L. Machado, M. Baylina, J. Tajan, J. Oristrell] Home intravenous antibiotic therapy is an alternative to hospital admission for moderately severe infections. However, few studies have analyzed its safety and effectiveness in the treatment of infections caused by multidrug-resistant bacteria. The purpose of this study is to analyze the safety and effectiveness of home intravenous antibiotic therapy in multidrug-resistant bacterial infections. We analyzed prospectively all patients admitted to our service who underwent home intravenous antibiotic therapy during the period 2008-2012. All the treatments were administered by caretakers or self-administered by patients, through elastomeric infusion devices. Effectiveness was evaluated by analyzing the readmission rate for poor infection control. Safety was evaluated by analyzing adverse events, catheter-related complications, and readmissions not related to poor infection control. There were 433 admissions (in 355 patients) for home intravenous antibiotic therapy during the study period. There were 226 (52.2%) admissions due to multidrug-resistant bacterial infections and 207 (47.8%) due to non-multidrug-resistant infections. Hospital readmissions in patients with multidrug-resistant infections were uncommon. Multidrug-resistant enterococcal infections, healthcare-associated infections, and carbapenem therapy were independent variables associated with increased readmissions due to poor infection control. Readmissions not related to poor infection control, adverse events, and catheter-related complications were similar in multidrug-resistant compared to non-multidrug-resistant bacterial infections. Home intravenous therapy, administered by patients or their caretakers using elastomeric infusion pumps, was safe and effective for the treatment of most multidrug-resistant bacterial infections. Springer-Verlag Berlin Heidelberg, 2015 Mujal A. Home Hospital Unit, Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut Sola J. Home Hospital Unit, Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut Hernandez M. Home Hospital Unit, Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut Villarino M.-A Acute Geriatric Unit, Albada Centre Sociosanitari, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut Machado M.-L Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut Baylina M. Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut Tajan J. Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut Oristrell J. Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1125-1133 0934-9723 34:6<1125 2015 34 10096 https://doi.org/10.1007/s10096-015-2330-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2330-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mujal A. Home Hospital Unit, Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut NATIONALLICENCE 700 1- Sola J. Home Hospital Unit, Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut NATIONALLICENCE 700 1- Hernandez M. Home Hospital Unit, Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut NATIONALLICENCE 700 1- Villarino M.-A Acute Geriatric Unit, Albada Centre Sociosanitari, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut NATIONALLICENCE 700 1- Machado M.-L Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut NATIONALLICENCE 700 1- Baylina M. Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut NATIONALLICENCE 700 1- Tajan J. Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut NATIONALLICENCE 700 1- Oristrell J. Department of Internal Medicine, Sabadell Hospital, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona, Parc Taulí s/n, 08208, Sabadell, Barcelona, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1125-1133 0934-9723 34:6<1125 2015 34 10096