caa a22 4500 606155619 CHVBK 20210128100604.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10096-015-2334-9 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2334-9 History of antimicrobial use and the risk of Dientamoeba fragilis infection [Elektronische Daten] [D. Röser, J. Simonsen, H. Nielsen, C. Stensvold, K. Mølbak] Associations between antimicrobial use and risk of enteric infection with intestinal protozoa are scarcely studied. The aim of this study was to quantify the risk of Dientamoeba fragilis infection conferred by exposure to antimicrobials. We conducted a registry-based retrospective cohort study of 9,945 Danish patients investigated for D. fragilis infection between 2008 and 2011, using data from the Danish Register of Medicinal Product Statistics, and calculating relative risks (RR) for D. fragilis infection by stratified binary regression. Furthermore, we conducted a population based case-control study using controls sampled from the Danish Civil Registration System, calculating hazard ratios (HR) for D. fragilis infection by conditional logistic regression. Exposure to metronidazole was found to confer decreased risk of D. fragilis infection; however, similar associations were found for antimicrobials not commonly used to treat D. fragilis, such as broad-spectrum penicillin, fluoroquinolones, and macrolides. In contrast, mebendazole exposure was associated with increased risk. The intake of antimicrobials influences the risk of D. fragilis. Springer-Verlag Berlin Heidelberg, 2015 Röser D. Department of Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut Simonsen J. Division of Health Surveillance and Research, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut Nielsen H. Department of Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut Stensvold C. Department of Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut Mølbak K. Division of Health Surveillance and Research, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1145-1151 0934-9723 34:6<1145 2015 34 10096 https://doi.org/10.1007/s10096-015-2334-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2334-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Röser D. Department of Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut NATIONALLICENCE 700 1- Simonsen J. Division of Health Surveillance and Research, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut NATIONALLICENCE 700 1- Nielsen H. Department of Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut NATIONALLICENCE 700 1- Stensvold C. Department of Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut NATIONALLICENCE 700 1- Mølbak K. Division of Health Surveillance and Research, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1145-1151 0934-9723 34:6<1145 2015 34 10096