caa a22 4500 606155635 CHVBK 20210128100604.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10096-015-2328-7 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2328-7 An algorithm to diagnose influenza infection: evaluating the clinical importance and impact on hospital costs of screening with rapid antigen detection tests [Elektronische Daten] [M. González-Del Vecchio, P. Catalán, V. de Egea, A. Rodríguez-Borlado, C. Martos, B. Padilla, B. Rodríguez-Sanchez, E. Bouza] Rapid antigen detection tests (RADTs) are immunoassays that produce results in 15min or less, have low sensitivity (50%), but high specificity (95%). We studied the clinical impact and laboratory savings of a diagnostic algorithm for influenza infection using RADTs as a first-step technique during the influenza season. From January 15th to March 31st 2014, we performed a diagnostic algorithm for influenza infection consisting of an RADT for all respiratory samples received in the laboratory. We studied all the patients with positive results for influenza infection, dividing them into two groups: Group A with a negative RADT but positive reference tests [reverse transcription polymerase chain reaction (RT-PCR) and/or culture] and Group B with an initial positive RADT. During the study period, we had a total of 1,156 patients with suspicion of influenza infection. Of them, 217 (19%) had a positive result for influenza: 132 (11%) had an initial negative RADT (Group A) and 85 (7%) had a positive RADT (Group B). When comparing patients in Group A and Group B, we found significant differences, as follows: prescribed oseltamivir (67% vs. 82%; p = 0.02), initiation of oseltamivir before 24h (89% vs. 97%; p = 0.03), antibiotics prescribed (89% vs. 67%; p = <0.01), intensive care unit (ICU) admissions after diagnosis (23% vs. 14%; p = 0.05), and need for supplementary oxygen (61% vs. 47%; p = 0.01). An influenza algorithm including RADTs as the first step improves the time of administration of proper antiviral therapy, reduces the use of antibiotics and ICU admissions, and decreases hospital costs. Springer-Verlag Berlin Heidelberg, 2015 González-Del Vecchio M. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut Catalán P. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut de Egea V. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut Rodríguez-Borlado A. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut Martos C. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut Padilla B. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut Rodríguez-Sanchez B. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut Bouza E. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1081-1085 0934-9723 34:6<1081 2015 34 10096 https://doi.org/10.1007/s10096-015-2328-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2328-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- González-Del Vecchio M. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- Catalán P. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- de Egea V. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- Rodríguez-Borlado A. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- Martos C. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- Padilla B. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- Rodríguez-Sanchez B. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 700 1- Bouza E. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1081-1085 0934-9723 34:6<1081 2015 34 10096