caa a22 4500 606155643 CHVBK 20210128100604.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10096-015-2335-8 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2335-8 Mycobacterium tuberculosis dormancy-associated antigen of Rv2660c induces stronger immune response in latent Mycobacterium tuberculosis infection than that in active tuberculosis in a Chinese population [Elektronische Daten] [H. He, H. Yang, Y. Deng] One-third of the world's human population is latently infected with Mycobacterium tuberculosis (M. tb), and adult tuberculosis (TB) is largely caused by the resuscitation of latent M. tb. Rv2660c, an M. tb dormancy-related antigen, is preferentially expressed during latent infection. Identification and characterization of Rv2660c are crucial to understanding host-pathogen interactions and to develop drug target and vaccine candidates. In this study, T-cell and antibody immune responses against recombinant Rv2660c protein were respectively investigated in latent M. tb infection (LTBI) cases, pulmonary tuberculosis (PTB) patients, and healthy individuals (HI). After stimulation with recombinant Rv2660c protein, stronger cellular responses were induced in LTBI cases compared with those in PTB patients or in HI. Meanwhile, Rv2660c stimulated higher levels of IgG, IgG1, and IgG2a antibody titers in LTBI cases compared with those in PTB patients. The results showed that Rv2660c is able to elicit prominent cellular immune responses and strong humoral immunity in a Chinese LTBI population, suggesting that Rv2660c is a potential target to develop new vaccines and drugs to control LTBI. Springer-Verlag Berlin Heidelberg, 2015 He H. Department of Human Anatomy, Academy of Preclinical and Forensic Medicine, West China Center of Medical Science, Sichuan University, No. 17, 3rd Section, Ren Min Nan Road, 610041, Chengdu, Sichuan, China aut Yang H. Department of Human Anatomy, Academy of Preclinical and Forensic Medicine, West China Center of Medical Science, Sichuan University, No. 17, 3rd Section, Ren Min Nan Road, 610041, Chengdu, Sichuan, China aut Deng Y. Department of Human Anatomy, Medical School, Kunming University of Science and Technology, Kunming, China aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1103-1109 0934-9723 34:6<1103 2015 34 10096 https://doi.org/10.1007/s10096-015-2335-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2335-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- He H. Department of Human Anatomy, Academy of Preclinical and Forensic Medicine, West China Center of Medical Science, Sichuan University, No. 17, 3rd Section, Ren Min Nan Road, 610041, Chengdu, Sichuan, China aut NATIONALLICENCE 700 1- Yang H. Department of Human Anatomy, Academy of Preclinical and Forensic Medicine, West China Center of Medical Science, Sichuan University, No. 17, 3rd Section, Ren Min Nan Road, 610041, Chengdu, Sichuan, China aut NATIONALLICENCE 700 1- Deng Y. Department of Human Anatomy, Medical School, Kunming University of Science and Technology, Kunming, China aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/6(2015-06-01), 1103-1109 0934-9723 34:6<1103 2015 34 10096