caa a22 4500 606155767 CHVBK 20210128100605.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10096-015-2411-0 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2411-0 Neonatal urinary tract infection may increase the risk of childhood asthma [Elektronische Daten] [C.-H. Lin, Y.-C. Wang, W.-C. Lin, C.-H. Kao] The aim of this population-based retrospective cohort study was to investigate the onset of urinary tract infection in newborns and the associated risks of childhood asthma. Children with neonatal UTI (n = 3,312) and randomly selected controls (n = 13,243) were enrolled for our analysis. We calculated the follow-up person-years for each participant from the index date until the diagnosis of asthma, the end of 2008, or withdrawal from the insurance system (because of death or loss to follow-up). Furthermore, we compared the risk of asthma between non-UTI and UTI cohorts by using Cox proportional hazards model analysis, the adjusted hazard ratio (aHR), and a 95% confidence interval (95% CI). The overall asthma incidence rate was found to be 1.53-fold significantly higher in the UTI cohort than in the non-UTI cohort (70.3 vs 45.8 per 1000 person-years). After we adjusted for potential risk factors, the overall risk of asthma remained higher in the UTI cohort (aHR = 1.47, 95% CI = 1.35-1.59). The incidence rate was higher in boys than in girls. Overall, patients suffering from UTI may have a greater risk of developing asthma than patients without UTI. This nationwide retrospective cohort study demonstrates that neonatal UTI may increase the risk of childhood asthma. Springer-Verlag Berlin Heidelberg, 2015 Lin C.-H Department of Pediatrics Children's Hospital, China Medical University Hospital, Taichung, Taiwan aut Wang Y.-C Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan aut Lin W.-C College of Medicine, China Medical University, Taichung, Taiwan aut Kao C.-H Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, 40447, Taichung, Taiwan aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/9(2015-09-01), 1773-1778 0934-9723 34:9<1773 2015 34 10096 https://doi.org/10.1007/s10096-015-2411-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2411-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin C.-H Department of Pediatrics Children's Hospital, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Wang Y.-C Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Lin W.-C College of Medicine, China Medical University, Taichung, Taiwan aut NATIONALLICENCE 700 1- Kao C.-H Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, 40447, Taichung, Taiwan aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/9(2015-09-01), 1773-1778 0934-9723 34:9<1773 2015 34 10096