caa a22 4500 606155783 CHVBK 20210128100605.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10096-015-2417-7 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2417-7 Fluoroquinolone-based antimicrobial prophylaxis in patients undergoing transrectal ultrasound-guided prostate biopsy [Elektronische Daten] [M. Sieczkowski, A. Gibas, M. Bronk, M. Matuszewski] The aim of this study was to establish the prevalence of resistance to fluoroquinolones in Escherichia coli strains isolated from patients undergoing transrectal ultrasound-guided prostate biopsy (TRUS-Bx) and to evaluate the incidence of possible infectious complications associated with this procedure. One hundred and four patients undergoing a TRUS-Bx in a single medical centre were prospectively enrolled in this study. In all patients, pre-biopsy rectal swabs were obtained. The analysis determined the antimicrobial susceptibility of E. coli strains to levofloxacin, ciprofloxacin and a panel of other antibiotics. Before biopsy, each of the men received a levofloxacin-based prophylaxis. Telephone follow-up was used to identify patients who had complications after TRUS-Bx. Fluoroquinolone-resistant strains were isolated from 9.62% of the patients. In all cases, there were related to E. coli and all those strains were resistant to both levofloxacin and ciprofloxacin. Fluoroquinolones showed greater antimicrobial activity against E. coli (p < 0.05) than ampicillin, amoxicillin/clavulanate and cephalothin. Minor infectious complications occurred in three patients (2.91%). The relation between the resistance of E. coli to fluoroquinolones and the risk of readmission, as well as infectious complications, was statistically significant (p < 0.05). Despite recent reports of increasing prevalence of fluoroquinolone-resistant E. coli and the associated increase of severe infectious complications, the presented results have not confirmed this phenomenon. Resistance to fluoroquinolones of E. coli strains isolated from rectal swab cultures prior to TRUS-Bx is the risk factor for readmission and infectious complications after this procedure. The Author(s), 2015 Sieczkowski M. Department of Urology, Medical University of Gdańsk, Gdańsk, Poland aut Gibas A. Department of Urology, Medical University of Gdańsk, Gdańsk, Poland aut Bronk M. Laboratory of Clinical Microbiology, University Clinical Centre in Gdańsk, Gdańsk, Poland aut Matuszewski M. Department of Urology, Medical University of Gdańsk, Gdańsk, Poland aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/9(2015-09-01), 1815-1821 0934-9723 34:9<1815 2015 34 10096 https://doi.org/10.1007/s10096-015-2417-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2417-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sieczkowski M. Department of Urology, Medical University of Gdańsk, Gdańsk, Poland aut NATIONALLICENCE 700 1- Gibas A. Department of Urology, Medical University of Gdańsk, Gdańsk, Poland aut NATIONALLICENCE 700 1- Bronk M. Laboratory of Clinical Microbiology, University Clinical Centre in Gdańsk, Gdańsk, Poland aut NATIONALLICENCE 700 1- Matuszewski M. Department of Urology, Medical University of Gdańsk, Gdańsk, Poland aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/9(2015-09-01), 1815-1821 0934-9723 34:9<1815 2015 34 10096