caa a22 4500 606155864 CHVBK 20210128100605.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10096-015-2433-7 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2433-7 −295 T-to-C promoter region IL-16 gene polymorphism is associated with Whipple's disease [Elektronische Daten] [F. Biagi, A. Schiepatti, C. Badulli, I. Sbarsi, L. Trotta, G. Feurle, C. Müller, V. Moos, T. Schneider, T. Marth, M. De Amici, M. Martinetti, G. Corazza] Whipple's disease (WD) is a rare systemic condition caused, in genetically predisposed subjects, by Tropheryma whipplei, a common bacterium widespread in the environment. The relevance of genetic predisposition in WD is shown by the association with HLA alleles DRB1*13 and DQB1*06 and by the demonstration that, in patients with WD, the cytokine genetic profile is skewed toward a Th2 and Treg response. Since IL-16 is involved in hampering the development of a protective macrophagic response against Tropheryma whipplei, we investigated whether the genetic background of IL-16 is different between patients with WD and controls. The −295T-to-C polymorphism of the promoter region of the IL-16 gene was studied in 90 patients with WD and 152 healthy controls. Levels of serum IL-16 protein were also tested. The frequency of the wild type T allele was significantly higher in patients with WD compared to the controls (155/180 vs. 235/304; p = 0.02 for the Chi2 test), odds ratio 1.82 [95% confidence interval (CI) 1.07-3.10]. The TT genotype was found in 65/90 patients with WD and 88/152 controls (p = 0.026). No relationship was found between serum levels of IL-16 and genotypes. Although the functional consequences of this genetic background on levels of IL-16 and on the course of the disease are still unknown, we found, for the first time, that the wild type T allele and the TT genotype of the −295 polymorphism are associated with WD. Springer-Verlag Berlin Heidelberg, 2015 Biagi F. First Department of Internal Medicine, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia, Italy aut Schiepatti A. First Department of Internal Medicine, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia, Italy aut Badulli C. Immunohematology and Transfusion Centre, IRCCS Foundation Policlinico San Matteo, Pavia, Italy aut Sbarsi I. Immunohematology and Transfusion Centre, IRCCS Foundation Policlinico San Matteo, Pavia, Italy aut Trotta L. First Department of Internal Medicine, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia, Italy aut Feurle G. DRK Krankenhaus, Neuwied, Germany aut Müller C. Universitätsklinik für Innere Medizin III, Klinische Abteilung Gastroenterologie und Hepatologie, Medizinische Universität Wien, Wien, Austria aut Moos V. Medizinische Klinik I, CBF, Charité—Universitätsmedizin Berlin, Berlin, Germany aut Schneider T. Medizinische Klinik I, CBF, Charité—Universitätsmedizin Berlin, Berlin, Germany aut Marth T. Abteilung Innere Medizin, Krankenhaus Maria Hilf, Daun, Germany aut De Amici M. Pediatriac Clinic, IRCCS Foundation Policlinico San Matteo, Pavia, Italy aut Martinetti M. Immunohematology and Transfusion Centre, IRCCS Foundation Policlinico San Matteo, Pavia, Italy aut Corazza G. First Department of Internal Medicine, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia, Italy aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/9(2015-09-01), 1919-1921 0934-9723 34:9<1919 2015 34 10096 https://doi.org/10.1007/s10096-015-2433-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2433-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Biagi F. First Department of Internal Medicine, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia, Italy aut NATIONALLICENCE 700 1- Schiepatti A. First Department of Internal Medicine, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia, Italy aut NATIONALLICENCE 700 1- Badulli C. Immunohematology and Transfusion Centre, IRCCS Foundation Policlinico San Matteo, Pavia, Italy aut NATIONALLICENCE 700 1- Sbarsi I. Immunohematology and Transfusion Centre, IRCCS Foundation Policlinico San Matteo, Pavia, Italy aut NATIONALLICENCE 700 1- Trotta L. First Department of Internal Medicine, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia, Italy aut NATIONALLICENCE 700 1- Feurle G. DRK Krankenhaus, Neuwied, Germany aut NATIONALLICENCE 700 1- Müller C. Universitätsklinik für Innere Medizin III, Klinische Abteilung Gastroenterologie und Hepatologie, Medizinische Universität Wien, Wien, Austria aut NATIONALLICENCE 700 1- Moos V. Medizinische Klinik I, CBF, Charité—Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Schneider T. Medizinische Klinik I, CBF, Charité—Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Marth T. Abteilung Innere Medizin, Krankenhaus Maria Hilf, Daun, Germany aut NATIONALLICENCE 700 1- De Amici M. Pediatriac Clinic, IRCCS Foundation Policlinico San Matteo, Pavia, Italy aut NATIONALLICENCE 700 1- Martinetti M. Immunohematology and Transfusion Centre, IRCCS Foundation Policlinico San Matteo, Pavia, Italy aut NATIONALLICENCE 700 1- Corazza G. First Department of Internal Medicine, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia, Italy aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/9(2015-09-01), 1919-1921 0934-9723 34:9<1919 2015 34 10096