caa a22 4500 606155902 CHVBK 20210128100606.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10096-015-2409-7 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2409-7 Prevalence of chronic pulmonary aspergillosis in patients with tuberculosis from Iran [Elektronische Daten] [M. Hedayati, Y. Azimi, A. Droudinia, B. Mousavi, A. Khalilian, N. Hedayati, D. Denning] In patients with preexisting lung disease, especially a cavity, Aspergillus can infect the surface of the cavity, causing chronic cavitary pulmonary aspergillosis (CCPA), and may form an aspergilloma, collectively called chronic pulmonary aspergillosis (CPA). In the present study, we assessed tuberculosis (TB) patients for CPA based on culture and serological methods. During a period of 1year (from March 2013 to March 2014), we studied 124 patients with TB (94 with current TB and 30 with previous TB) at Masih Daneshvari Hospital in Tehran, Iran. Sputum specimens were analyzed by direct microscopic examination (DME) and fungal culture. The clinical and radiological features of all patients were recorded, to categorize the patients into CCPA and aspergilloma. All patients were screened for serum-specific IgG against A. fumigatus, by enzyme-linked immunosorbent assay (ELISA). Out of 124 patients with TB (66 male, age range: 10-91years), 48 patients (38.7%) exhibited residual cavities. Eighteen (14.5%) patients had cavities with pleural thickening. A round-shaped mass lesion was detected in six patients (6.8%). DME was positive in ten patients for septate fungal hyphae. A. fumigatus was grown from 14 samples. Fifty-five (44.3%) cases were positive for serum-specific IgG against A. fumigatus. Of 124 patients with TB, 3 (2.4%) met criteria for aspergilloma and 14 (11.3%) for CCPA. CPA is a common clinical presentation in individuals with healed TB in Iran, as reported by previous studies from other countries. Springer-Verlag Berlin Heidelberg, 2015 Hedayati M. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Km 18 Khazarabad Road, P.O. Box 48175-1665, Sari, Iran aut Azimi Y. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Km 18 Khazarabad Road, P.O. Box 48175-1665, Sari, Iran aut Droudinia A. Transplantation Research Center, National Research Institute for Tuberculosis and Lung Disease, Masih Daneshvari Hospital, Shaheed Beheshti University of Medical Science, Tehran, Iran aut Mousavi B. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Km 18 Khazarabad Road, P.O. Box 48175-1665, Sari, Iran aut Khalilian A. Department of Statistics, School of Medicine, Mazandaran University of Medical Science, Sari, Iran aut Hedayati N. Ramsar International Branch, Mazandaran University of Medical Sciences, Sari, Iran aut Denning D. The National Aspergillosis Centre, University Hospital of South Manchester, University of Manchester, Manchester, UK aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/9(2015-09-01), 1759-1765 0934-9723 34:9<1759 2015 34 10096 https://doi.org/10.1007/s10096-015-2409-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2409-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hedayati M. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Km 18 Khazarabad Road, P.O. Box 48175-1665, Sari, Iran aut NATIONALLICENCE 700 1- Azimi Y. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Km 18 Khazarabad Road, P.O. Box 48175-1665, Sari, Iran aut NATIONALLICENCE 700 1- Droudinia A. Transplantation Research Center, National Research Institute for Tuberculosis and Lung Disease, Masih Daneshvari Hospital, Shaheed Beheshti University of Medical Science, Tehran, Iran aut NATIONALLICENCE 700 1- Mousavi B. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Km 18 Khazarabad Road, P.O. Box 48175-1665, Sari, Iran aut NATIONALLICENCE 700 1- Khalilian A. Department of Statistics, School of Medicine, Mazandaran University of Medical Science, Sari, Iran aut NATIONALLICENCE 700 1- Hedayati N. Ramsar International Branch, Mazandaran University of Medical Sciences, Sari, Iran aut NATIONALLICENCE 700 1- Denning D. The National Aspergillosis Centre, University Hospital of South Manchester, University of Manchester, Manchester, UK aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/9(2015-09-01), 1759-1765 0934-9723 34:9<1759 2015 34 10096