caa a22 4500 606155988 CHVBK 20210128100606.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10096-015-2364-3 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2364-3 Coagulase-negative staphylococcal bacteremia: risk factors for mortality and impact of initial appropriate antimicrobial therapy on outcome [Elektronische Daten] [S. Park, K. Kwon, J.-W. Chung, H. Huh, S. Chae] It is uncertain whether an initial inappropriate empirical antibiotic treatment of coagulase-negative staphylococci (CoNS) bacteremia adversely affects the outcome. A retrospective cohort study of CoNS bacteremia was performed at the Dongguk University Ilsan Hospital during a 3-year period. During the study period, 109 patients with CoNS bacteremia were enrolled. The median age of the patients was 72 years and most (96%, 105/109) had one or more comorbid diseases. Among the participants, 29% (32/109) received an appropriate empirical antimicrobial therapy. The 30-day mortality was 24% (26/109) and CoNS bacteremia-related mortality was 14% (15/109). There was no difference in the CoNS bacteremia-related mortality between the group with an inappropriate empirical treatment (13%, 10/77) and that with an appropriate treatment (16%, 5/32) (p = 0.46). In the multivariate analysis using the Cox regression analysis method, Pitt bacteremia scores [hazard ratio (HR) 1.48; 95% confidence interval (CI) 1.09-2.01; p = 0.01] and retention of eradicable focus (HR 5.0; 95% CI 1.39-17.9; p = 0.01) were found to be associated with CoNS bacteremia-related mortality. The results suggest that inappropriate empirical therapy might not necessarily be associated with the 30-day mortality or CoNS bacteremia-related mortality. Conversely, Pitt bacteremia scores and retention of eradicable focus were associated with poor outcomes. Springer-Verlag Berlin Heidelberg, 2015 Park S. Divisions of Infectious Diseases, Department of Internal Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut Kwon K. Divisions of Infectious Diseases, Department of Internal Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut Chung J.-W Department of Laboratory Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut Huh H. Department of Laboratory Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut Chae S. Department of Laboratory Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/7(2015-07-01), 1395-1401 0934-9723 34:7<1395 2015 34 10096 https://doi.org/10.1007/s10096-015-2364-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2364-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park S. Divisions of Infectious Diseases, Department of Internal Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Kwon K. Divisions of Infectious Diseases, Department of Internal Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Chung J.-W Department of Laboratory Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Huh H. Department of Laboratory Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Chae S. Department of Laboratory Medicine, Dongguk University, Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, 410-773, Goyang-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/7(2015-07-01), 1395-1401 0934-9723 34:7<1395 2015 34 10096