caa a22 4500 606156062 CHVBK 20210128100606.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10096-015-2361-6 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2361-6 Cyst infection in autosomal dominant polycystic kidney disease: causative microorganisms and susceptibility to lipid-soluble antibiotics [Elektronische Daten] [T. Suwabe, H. Araoka, Y. Ubara, K. Kikuchi, R. Hazue, K. Mise, S. Hamanoue, T. Ueno, K. Sumida, N. Hayami, J. Hoshino, A. Imafuku, M. Kawada, R. Hiramatsu, E. Hasegawa, N. Sawa, K. Takaichi] Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD). Lipid-soluble antibiotics like fluoroquinolones show good penetration into cysts and are recommended for cyst infection, but causative microorganisms are often resistant to these agents. This study investigated the profile of the microorganisms causing cyst infection in ADPKD, their susceptibility to lipid-soluble antibiotics, and clinical outcomes. This retrospective study reviewed all ADPKD patients admitted to Toranomon Hospital with a diagnosis of cyst infection from January 2004 to March 2014. All patients who underwent cyst drainage and had positive cyst fluid cultures were enrolled. Patients with positive blood cultures who satisfied our criteria for cyst infection or probable infection were also enrolled. There were 99 episodes with positive cyst fluid cultures and 93 episodes with positive blood cultures. The majority of patients were on dialysis. The death rate was high when infection was caused by multiple microorganisms or when there were multiple infected cysts. Gram-negative bacteria accounted for 74-79% of the isolates in all groups, except for patients with positive hepatic cyst fluid cultures. The susceptibility of Escherichia coli to fluoroquinolones was very low in patients with hepatic cyst infection, especially those with frequent episodes and those with hepatomegaly. Fungi were detected in two episodes. Fluoroquinolone-resistant microorganisms showed a high prevalence in cyst infection. It is important to identify causative microorganisms to avoid the overuse of fluoroquinolones and to improve the outcome of cyst infection in ADPKD. Springer-Verlag Berlin Heidelberg, 2015 Suwabe T. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Araoka H. Department of Infectious Diseases, Toranomon Hospital, Tokyo, Japan aut Ubara Y. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Kikuchi K. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Hazue R. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Mise K. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Hamanoue S. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Ueno T. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Sumida K. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Hayami N. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Hoshino J. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut Imafuku A. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut Kawada M. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut Hiramatsu R. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut Hasegawa E. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut Sawa N. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut Takaichi K. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/7(2015-07-01), 1369-1379 0934-9723 34:7<1369 2015 34 10096 https://doi.org/10.1007/s10096-015-2361-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2361-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suwabe T. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Araoka H. Department of Infectious Diseases, Toranomon Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Ubara Y. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kikuchi K. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Hazue R. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Mise K. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Hamanoue S. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Ueno T. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Sumida K. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Hayami N. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Hoshino J. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Imafuku A. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Kawada M. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Hiramatsu R. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Hasegawa E. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Sawa N. Department of Nephrology, Toranomon Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Takaichi K. Department of Nephrology, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya, Takatsu-ku, 213-8587, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/7(2015-07-01), 1369-1379 0934-9723 34:7<1369 2015 34 10096