caa a22 4500 606156097 CHVBK 20210128100606.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10096-015-2337-6 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2337-6 TBX 21 polymorphisms are associated with virus persistence in hepatitis C virus infection patients from a high-risk Chinese population [Elektronische Daten] [D. Zhu, L. Jiang, X. Deng, W. Xiao, J. Pei, B. Li, C. Wang, J. Zhang, Q. Zhang, Z. Zhou, W. Ding, X. Xu, M. Yue] Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and the varied outcomes of the infection depend on both viral and host factors. We have demonstrated that the HCV alternate reading frame protein (F protein) is related to Th1/Th2 bias which is involved in virus persistence in chronic hepatitis C (CHC) patients. The purpose of this study was to test the hypothesis that genetic variants of TBX21 (T cell specific T-box transcription factor) were associated with the outcomes of HCV infection and F protein generation. Three single nucleotide polymorphisms (SNPs) (rs17250932, rs2074190, rs4794067) in the TBX21 gene were genotyped in a case-control study in a cohort of a high-risk group, including 354 healthy controls and 747 CHC patients (190 anti-F protein antibody seronegative patients and 557 anti-F protein antibody seropositive patients). Results showed that the rs4794067 C allele in the TBX21 promoter was significantly more common in CHC patients (OR = 1.335, 95% CI = 1.058-1.684, P = 0.015), exceptionally in anti-F protein seropositive patients (OR = 1.547, 95% CI = 1.140-2.101, P = 0.005), compared with healthy controls. And the risk effect was also significantly high in patients with HCV 1b genotype and mild fibrosis (P = 0.021, P = 0.010, respectively). Compared with the most frequent haplotype TAT, haplotype analysis showed that the distribution of TAC was significantly different between the chronic HCV carrier group and the healthy group, and so was the anti-F antibody seronegativity group and the anti-F antibody seronegativity group (all P < 0.001). Our results suggested that TBX21 variants may be involved in the etiology of this disease. Springer-Verlag Berlin Heidelberg, 2015 Zhu D. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, No. 293, Zhongshan East Road, 210002, Nanjing, China aut Jiang L. Department of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China aut Deng X. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, No. 293, Zhongshan East Road, 210002, Nanjing, China aut Xiao W. School of Life Science and Technology, China Pharmaceutical University, Nanjing, China aut Pei J. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, No. 293, Zhongshan East Road, 210002, Nanjing, China aut Li B. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut Wang C. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut Zhang J. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut Zhang Q. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut Zhou Z. Department of Clinical Laboratory, Nanjing Second Hospital, Nanjing, China aut Ding W. Department of Clinical Laboratory, Yixing People's Hospital, Yixing, China aut Xu X. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut Yue M. School of Life Science and Technology, China Pharmaceutical University, Nanjing, China aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/7(2015-07-01), 1309-1318 0934-9723 34:7<1309 2015 34 10096 https://doi.org/10.1007/s10096-015-2337-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2337-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu D. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, No. 293, Zhongshan East Road, 210002, Nanjing, China aut NATIONALLICENCE 700 1- Jiang L. Department of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China aut NATIONALLICENCE 700 1- Deng X. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, No. 293, Zhongshan East Road, 210002, Nanjing, China aut NATIONALLICENCE 700 1- Xiao W. School of Life Science and Technology, China Pharmaceutical University, Nanjing, China aut NATIONALLICENCE 700 1- Pei J. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, No. 293, Zhongshan East Road, 210002, Nanjing, China aut NATIONALLICENCE 700 1- Li B. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut NATIONALLICENCE 700 1- Wang C. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut NATIONALLICENCE 700 1- Zhang J. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut NATIONALLICENCE 700 1- Zhang Q. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut NATIONALLICENCE 700 1- Zhou Z. Department of Clinical Laboratory, Nanjing Second Hospital, Nanjing, China aut NATIONALLICENCE 700 1- Ding W. Department of Clinical Laboratory, Yixing People's Hospital, Yixing, China aut NATIONALLICENCE 700 1- Xu X. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, 210002, Nanjing, China aut NATIONALLICENCE 700 1- Yue M. School of Life Science and Technology, China Pharmaceutical University, Nanjing, China aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/7(2015-07-01), 1309-1318 0934-9723 34:7<1309 2015 34 10096