caa a22 4500 606156127 CHVBK 20210128100607.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10096-015-2357-2 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2357-2 Prevalence of Whipple's disease in north-western Italy [Elektronische Daten] [F. Biagi, D. Balduzzi, P. Delvino, A. Schiepatti, C. Klersy, G. Corazza] Whipple's disease (WD) is a rare systemic infection due, in genetically susceptible individuals, to Tropheryma whipplei, a heterogeneous Gram-positive actinobacteria. Although it has already been recognised that WD affects mainly middle-aged Caucasian men, the prevalence of WD is virtually unknown. The annual incidence of WD in the general population is said to be less than 1 per 1,000,000, but scientific evidence for these figures is still lacking. On the basis of the number of patients recorded with a diagnosis of Whipple's disease in the regional registers for rare diseases of Lombardia, Liguria and Piemonte-Valle d'Aosta regions, we studied the prevalence of WD in the north-western part of Italy. Forty-six patients with Whipple's disease were recorded in these regions (13 females; mean age at diagnosis 52.1 ± 11.1years). Since 16,130,725 inhabitants live in these four regions, prevalence of WD in the general population is 3/106 and almost 30% of the patients are females. WD is certainly a rare disease but it also affects women in a considerable proportion of cases. Springer-Verlag Berlin Heidelberg, 2015 Biagi F. Coeliac Centre/First Dept of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, P.le Golgi, 19, 27100, Pavia, Italy aut Balduzzi D. Coeliac Centre/First Dept of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, P.le Golgi, 19, 27100, Pavia, Italy aut Delvino P. Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy aut Schiepatti A. Coeliac Centre/First Dept of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, P.le Golgi, 19, 27100, Pavia, Italy aut Klersy C. Biometry and Clinical Epidemiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy aut Corazza G. Coeliac Centre/First Dept of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, P.le Golgi, 19, 27100, Pavia, Italy aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/7(2015-07-01), 1347-1348 0934-9723 34:7<1347 2015 34 10096 https://doi.org/10.1007/s10096-015-2357-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2357-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Biagi F. Coeliac Centre/First Dept of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, P.le Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Balduzzi D. Coeliac Centre/First Dept of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, P.le Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Delvino P. Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy aut NATIONALLICENCE 700 1- Schiepatti A. Coeliac Centre/First Dept of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, P.le Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Klersy C. Biometry and Clinical Epidemiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy aut NATIONALLICENCE 700 1- Corazza G. Coeliac Centre/First Dept of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, P.le Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/7(2015-07-01), 1347-1348 0934-9723 34:7<1347 2015 34 10096