caa a22 4500 606156208 CHVBK 20210128100607.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10096-015-2486-7 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2486-7 Combination therapy for carbapenem-resistant Enterobacteriaceae: increasing evidence, unanswered questions, potential solutions [Elektronische Daten] [L. Nabarro, B. Veeraraghavan] Carbapenem-resistant Enterobacteriaceae (CRE) are associated with a high mortality rate and are an increasing problem worldwide. In this mini-review, we consider the growing number of observational studies in favour of combination therapy but highlight the absence of randomised control trials. We discuss the importance of data on minimum inhibitory concentrations (MICs), both for surveillance and for individual patient management. We examine the issues surrounding the use of carbapenems, polymyxins and tigecycline in the treatment of CRE. When and how should we be using carbapenems? Which polymyxin is best? Is tigecycline much maligned? Further studies are urgently needed to validate drug combinations, doses and ratios to maximise efficacy whilst reducing drug exposure and adverse effects. Springer-Verlag Berlin Heidelberg, 2015 Nabarro L. Public Health England, London, UK aut Veeraraghavan B. Department of Microbiology, Christian Medical College, Vellore, Tamil Nadu, India aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/12(2015-12-01), 2307-2311 0934-9723 34:12<2307 2015 34 10096 https://doi.org/10.1007/s10096-015-2486-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2486-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nabarro L. Public Health England, London, UK aut NATIONALLICENCE 700 1- Veeraraghavan B. Department of Microbiology, Christian Medical College, Vellore, Tamil Nadu, India aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/12(2015-12-01), 2307-2311 0934-9723 34:12<2307 2015 34 10096