caa a22 4500 606156275 CHVBK 20210128100607.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10096-015-2500-0 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2500-0 -572 G/C single nucleotide polymorphism of interleukin-6 and sepsis predisposition in chronic renal disease [Elektronische Daten] [A. Panayides, A. Ioakeimidou, V. Karamouzos, N. Antonakos, I. Koutelidakis, G. Giannikopoulos, K. Makaritsis, N. Voloudakis, K. Toutouzas, N. Rovina, M. Bristianou, G. Damoraki, C. Routsi, E. Giamarellos-Bourboulis] Single nucleotide polymorphisms (SNPs) of interleukin (IL)-6 are associated with the development of chronic renal disease (CRD). Their impact for sepsis in the field of CRD was investigated. One control cohort of 115 patients with CRD without infection and another case cohort of 198 patients with CRD and sepsis were enrolled. Genotyping at the −174 (rs1800795) and −572 positions of IL-6 (rs1800796) was done by restriction fragment length polymorphism. Circulating IL-6 was measured by an enzyme immunoassay. The GG genotype of rs1800796 was more frequent among cases (78.3%) than controls (62.6%). No difference in the genotype frequencies of rs1800795 between cases and controls were found. Odds ratio for sepsis was 2.07 (95%CI 1.24-3.44, p = 0.005) with the GG genotype of rs1800796, which was confirmed by logistic regression analysis taking into consideration the presence of chronic comorbidities. All-cause mortality until day 28 was similar between patients with the GG genotype and the GC/CC genotypes of rs1800796, but death caused from cardiovascular events not-related with infection was more frequent with the GG genotype (14.6% vs 2.4%, p = 0.031). Circulating IL-6 was greater among patients of the GC/CC genotypes of rs1800796 and multiple organ dysfunction (p = 0.013). The GG genotype of rs1800796 predisposes to sepsis in CRD and to 28-day mortality by sepsis-unrelated cardiovascular phenomena. Springer-Verlag Berlin Heidelberg, 2015 Panayides A. Department of Nephrology, Nicosia General Hospital, Nicosia, Cyprus aut Ioakeimidou A. Intensive Care Unit, Korinthos General Hospital, Korinthos, Greece aut Karamouzos V. Department of Internal Medicine, Rion University Hospital, Patras, Greece aut Antonakos N. 4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece aut Koutelidakis I. 2nd Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece aut Giannikopoulos G. Department of Internal Medicine, Chios General Hospital, Chios, Greece aut Makaritsis K. Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa, Greece aut Voloudakis N. 2nd Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece aut Toutouzas K. 1st Department of Propaedeutic Surgery, University of Athens, Medical School, Athens, Greece aut Rovina N. 1st Department of Pulmonary Medicine and Intensive Care Unit, University of Athens, Medical School, Athens, Greece aut Bristianou M. Department of Urology, Lamia General Hospital, Lamia, Greece aut Damoraki G. 4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece aut Routsi C. 1st Department of Critical Care Medicine, University of Athens, Medical School, Athens, Greece aut Giamarellos-Bourboulis E. 4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/12(2015-12-01), 2439-2446 0934-9723 34:12<2439 2015 34 10096 https://doi.org/10.1007/s10096-015-2500-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2500-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Panayides A. Department of Nephrology, Nicosia General Hospital, Nicosia, Cyprus aut NATIONALLICENCE 700 1- Ioakeimidou A. Intensive Care Unit, Korinthos General Hospital, Korinthos, Greece aut NATIONALLICENCE 700 1- Karamouzos V. Department of Internal Medicine, Rion University Hospital, Patras, Greece aut NATIONALLICENCE 700 1- Antonakos N. 4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Koutelidakis I. 2nd Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Giannikopoulos G. Department of Internal Medicine, Chios General Hospital, Chios, Greece aut NATIONALLICENCE 700 1- Makaritsis K. Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa, Greece aut NATIONALLICENCE 700 1- Voloudakis N. 2nd Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Toutouzas K. 1st Department of Propaedeutic Surgery, University of Athens, Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Rovina N. 1st Department of Pulmonary Medicine and Intensive Care Unit, University of Athens, Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Bristianou M. Department of Urology, Lamia General Hospital, Lamia, Greece aut NATIONALLICENCE 700 1- Damoraki G. 4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Routsi C. 1st Department of Critical Care Medicine, University of Athens, Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Giamarellos-Bourboulis E. 4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/12(2015-12-01), 2439-2446 0934-9723 34:12<2439 2015 34 10096