caa a22 4500 606156283 CHVBK 20210128100607.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10096-015-2485-8 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2485-8 Triclosan-coated sutures and sternal wound infections: a prospective randomized clinical trial [Elektronische Daten] [S. Steingrimsson, L. Thimour-Bergström, C. Roman-Emanuel, H. Scherstén, Ö. Friberg, T. Gudbjartsson, A. Jeppsson] Surgical site infection is a common complication following cardiac surgery. Triclosan-coated sutures have been shown to reduce the rate of infections in various surgical wounds, including wounds after vein harvesting in coronary artery bypass grafting patients. Our purpose was to compare the rate of infections in sternotomy wounds closed with triclosan-coated or conventional sutures. A total of 357 patients that underwent coronary artery bypass grafting were included in a prospective randomized double-blind single-center study. The patients were randomized to closure of the sternal wound with either triclosan-coated sutures (Vicryl Plus and Monocryl Plus, Ethicon, Inc., Somerville, NJ, USA) (n = 179) or identical sutures without triclosan (n = 178). Patients were followed up after 30days (clinical visit) and 60days (telephone interview). The primary endpoint was the prevalence of sternal wound infection according to the Centers for Disease Control and Prevention (CDC) criteria. The demographics in both groups were comparable, including age, gender, body mass index, and rate of diabetes and smoking. Sternal wound infection was diagnosed in 43 patients; 23 (12.8%) sutured with triclosan-coated sutures compared to 20 (11.2%) sutured without triclosan (p = 0.640). Most infections were superficial (n = 36, 10.1%), while 7 (2.0%) were deep sternal wound infections. There were 16 positive cultures in the triclosan group and 17 in the non-coated suture group (p = 0.842). The most commonly identified main pathogens were Staphylococcus aureus (45.4%) and coagulase-negative staphylococci (36.4%). Skin closure with triclosan-coated sutures did not reduce the rate of sternal wound infection after coronary artery bypass grafting. (clinicaltrials.gov: NCT01212315) Springer-Verlag Berlin Heidelberg, 2015 Steingrimsson S. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut Thimour-Bergström L. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut Roman-Emanuel C. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut Scherstén H. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut Friberg Ö. Department of Cardiothoracic Surgery, University Hospital, Örebro, Sweden aut Gudbjartsson T. Landspitali University Hospital, Faculty of Medicine, University of Iceland, Reykjavik, Iceland aut Jeppsson A. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/12(2015-12-01), 2331-2338 0934-9723 34:12<2331 2015 34 10096 https://doi.org/10.1007/s10096-015-2485-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2485-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Steingrimsson S. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Thimour-Bergström L. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Roman-Emanuel C. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Scherstén H. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Friberg Ö. Department of Cardiothoracic Surgery, University Hospital, Örebro, Sweden aut NATIONALLICENCE 700 1- Gudbjartsson T. Landspitali University Hospital, Faculty of Medicine, University of Iceland, Reykjavik, Iceland aut NATIONALLICENCE 700 1- Jeppsson A. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/12(2015-12-01), 2331-2338 0934-9723 34:12<2331 2015 34 10096