caa a22 4500 606156372 CHVBK 20210128100608.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10096-014-2256-y doi (NATIONALLICENCE)springer-10.1007/s10096-014-2256-y Invasive Propionibacterium acnes infections in a non-selective patient cohort: clinical manifestations, management and outcome [Elektronische Daten] [M. Tebruegge, C. Jones, H. de Graaf, P. Sukhtankar, R. Allan, R. Howlin, D. Browning, H. Schuster, A. Pallett, S. Patel, S. Faust] An increasing number of reports suggest that Propionibacterium acnes can cause serious invasive infections. Currently, only limited data exist regarding the spectrum of invasive P. acnes infections. We conducted a non-selective cohort study at a tertiary hospital in the UK over a 9-year-period (2003-2012) investigating clinical manifestations, risk factors, management, and outcome of invasive P. acnes infections. Forty-nine cases were identified; the majority were neurosurgical infections and orthopaedic infections (n = 28 and n = 15 respectively). Only 2 cases had no predisposing factors; all neurosurgical and 93.3% of orthopaedic cases had a history of previous surgery and/or trauma. Foreign material was in situ at the infection site in 59.3% and 80.0% of neurosurgical and orthopaedic cases respectively. All neurosurgical and orthopaedic cases required one or more surgical interventions to treat P. acnes infection, with or without concomitant antibiotic therapy; the duration of antibiotic therapy was significantly longer in the group of orthopaedic cases (median 53 vs 19days; p = 0.0025). All tested P. acnes isolates were susceptible to penicillin, ampicillin and chloramphenicol; only 1 was clindamycin-resistant. Neurosurgical and orthopaedic infections account for the majority of invasive P. acnes infections. Most cases have predisposing factors, including previous surgery and/or trauma; spontaneous infections are rare. Foreign material is commonly present at the site of infection, indicating that the pathogenesis of invasive P. acnes infections likely involves biofilm formation. Since invasive P. acnes infections are associated with considerable morbidity, further studies are needed to establish effective prevention and optimal treatment strategies. Springer-Verlag Berlin Heidelberg, 2014 Tebruegge M. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut Jones C. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut de Graaf H. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut Sukhtankar P. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut Allan R. Southampton National Institute for Health Research Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut Howlin R. Institute for Life Sciences, University of Southampton, Southampton, UK aut Browning D. Department of Microbiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut Schuster H. Department of Microbiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut Pallett A. Department of Microbiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut Patel S. Department of Paediatric Immunology & Infectious Diseases, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut Faust S. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/3(2015-03-01), 527-534 0934-9723 34:3<527 2015 34 10096 https://doi.org/10.1007/s10096-014-2256-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2256-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tebruegge M. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut NATIONALLICENCE 700 1- Jones C. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut NATIONALLICENCE 700 1- de Graaf H. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut NATIONALLICENCE 700 1- Sukhtankar P. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut NATIONALLICENCE 700 1- Allan R. Southampton National Institute for Health Research Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut NATIONALLICENCE 700 1- Howlin R. Institute for Life Sciences, University of Southampton, Southampton, UK aut NATIONALLICENCE 700 1- Browning D. Department of Microbiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut NATIONALLICENCE 700 1- Schuster H. Department of Microbiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut NATIONALLICENCE 700 1- Pallett A. Department of Microbiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut NATIONALLICENCE 700 1- Patel S. Department of Paediatric Immunology & Infectious Diseases, University Hospital Southampton NHS Foundation Trust, Southampton, UK aut NATIONALLICENCE 700 1- Faust S. Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/3(2015-03-01), 527-534 0934-9723 34:3<527 2015 34 10096