caa a22 4500 606156569 CHVBK 20210128100609.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10096-014-2270-0 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2270-0 Lamivudine treatment and outcome in pregnant women with high hepatitis B viral loads [Elektronische Daten] [V. Jackson, W. Ferguson, T. Kelleher, M. Lawless, M. Eogan, U. Nusgen, S. Coughlan, J. Connell, J. Lambert] Perinatal transmission is the most common mode of hepatitis B virus (HBV) transmission and is a leading cause of chronic infection worldwide. Maternal treatment with lamivudine (LAM) can result in a rapid and significant reduction in HBV viral load (VL) and, thus, mitigate the risk of mother-to-child transmission (MTCT). The aim of this study was to retrospectively evaluate the safety of LAM treatment administered in the third trimester of pregnancy and determine the influence, if any, on infant outcome. The medical charts of all HBV surface antigen (HBsAg)-positive women eligible for treatment with LAM and who registered for antenatal care between 2007 and 2012 were retrospectively reviewed. During the 6-year period, 45 women met the criteria for LAM treatment. Thirty-six women (80%) accepted treatment; the remaining women declined treatment (5), defaulted from care (3) or transferred to another maternity unit (1). The median duration of treatment was 11.4weeks (range 5.3-17.4) and the median baseline VL was 1.4 × 108IU/mL (range 1.8 × 107-1.7 × 108). The median VL at delivery was 2.3 × 105IU/mL and 60% of women achieved a VL reduction >2 log10 IU/mL before delivery. No cases of perinatal transmission occurred in the infants born to mothers who received treatment; however, one infant, born to a mother who defaulted from care, was HBV-infected at 8 months. The results suggest that LAM therapy in highly viraemic HBV-infected pregnant women could lower the rate of vertical transmission. Springer-Verlag Berlin Heidelberg, 2014 Jackson V. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut Ferguson W. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut Kelleher T. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut Lawless M. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut Eogan M. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut Nusgen U. Department of Microbiology, The Rotunda Hospital, Dublin, Ireland aut Coughlan S. The National Virus Reference Laboratory, University College Dublin, Dublin, Ireland aut Connell J. The National Virus Reference Laboratory, University College Dublin, Dublin, Ireland aut Lambert J. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/3(2015-03-01), 619-623 0934-9723 34:3<619 2015 34 10096 https://doi.org/10.1007/s10096-014-2270-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2270-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jackson V. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Ferguson W. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Kelleher T. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Lawless M. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Eogan M. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Nusgen U. Department of Microbiology, The Rotunda Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Coughlan S. The National Virus Reference Laboratory, University College Dublin, Dublin, Ireland aut NATIONALLICENCE 700 1- Connell J. The National Virus Reference Laboratory, University College Dublin, Dublin, Ireland aut NATIONALLICENCE 700 1- Lambert J. Department of Infectious Diseases, The Rotunda Hospital, Dublin, Ireland aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/3(2015-03-01), 619-623 0934-9723 34:3<619 2015 34 10096